2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetonitrile CAS 1806159-75-0
| CAS No. | 1806159-75-0 |
| Molecular Formula | C9H5F5N2O2 |
| Molecular Weight | 268.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetonitrile (CAS 1806159-75-0), molecular formula C9H5F5N2O2 and molecular weight 268.14 g/mol, is a CATO reference standard with documented purity and traceability.
2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetonitrile (C9H5F5N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures 2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H5F5N2O2 |
| Molecular Weight | 268.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-3-hydroxy-5-(trifluoromethoxy)pyridine-6-acetonitrile (CAS 1803959-84-3)
- 2-(4-(Difluoromethyl)-2-hydroxy-6-(trifluoromethoxy)pyridin-3-yl)acetonitrile (CAS 1804347-30-5)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)pyridin-2-yl)acetonitrile (CAS 1804360-63-1)
- 2-(Difluoromethyl)-3-hydroxy-5-(trifluoromethoxy)pyridine-4-acetonitrile (CAS 1804477-96-0)
- 2-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridine-4-acetonitrile (CAS 1804478-02-1)
- 2-(4-(Difluoromethyl)-2-hydroxy-5-(trifluoromethoxy)pyridin-3-yl)acetonitrile (CAS 1804478-36-1)
- 2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-acetonitrile (CAS 1804725-55-0)
- 2-(2-(Difluoromethyl)-6-hydroxy-3-(trifluoromethoxy)pyridin-4-yl)acetonitrile (CAS 1804796-73-3)
Recommended Standards
- 4-Chloro-3-cyano-2-mercaptobenzene-1-sulfonyl chloride (CAS 1806075-41-1)
- 2-(Difluoromethyl)-3-hydroxy-4-(trifluoromethoxy)pyridine-5-acetonitrile (CAS 1806727-05-8)
- 2-(4-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridin-2-yl)acetonitrile (CAS 1804839-51-7)
- 4-Chloro-3-cyano-5-mercaptobenzene-1-sulfonyl chloride (CAS 1807211-78-4)
- 6-Fluoroimidazo[1,2-a]pyridine-2-carbonyl chloride (CAS 503455-75-2)
- Isopropyl icosanoate (CAS 26718-90-1)
- 2-Chloro-1-fluoro-3-(trichloromethoxy)benzene (CAS 1404193-79-8)
- N-(5-(1H-Imidazol-5-yl)pentyl)cyclohexanamine (CAS 397248-40-7)
- 2-(3-fluorophenoxy)propan-1-amine hydrochloride (CAS 1021871-65-7)
- 1-Chloropinacolone (CAS 13547-70-1)
- 2-(Decyloxy)isoindoline-1,3-dione (CAS 1621487-67-9)
- 1-Methyl-2-phenylbenzo[cd]indol-5(1H)-one (CAS 75528-58-4)
- 3,5-Dibromo-6-(trifluoromethyl)pyridin-2-amine (CAS 1291487-16-5)
- D-Asp9-Tirzepatide (CAS CATO-CPTD788923)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com