2-(Difluoromethyl)-3-methoxy-5-(trifluoromethoxy)pyridine-6-carboxylic acid CAS 1806255-13-9
| CAS No. | 1806255-13-9 |
| Molecular Formula | C9H6F5NO4 |
| Molecular Weight | 287.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(Difluoromethyl)-3-methoxy-5-(trifluoromethoxy)pyridine-6-carboxylic acid (C9H6F5NO4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-(Difluoromethyl)-3-methoxy-5-(trifluoromethoxy)pyridine-6-carboxylic acid (CAS 1806255-13-9), molecular formula C9H6F5NO4 and molecular weight 287.14 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6F5NO4 |
| Molecular Weight | 287.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(4-(Difluoromethyl)-5-hydroxy-3-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1803963-01-0)
- 2-(Difluoromethyl)-3-hydroxy-5-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804359-32-7)
- 4-(Difluoromethyl)-6-methoxy-5-(trifluoromethoxy)nicotinic acid (CAS 1804479-67-1)
- 2-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridine-5-acetic acid (CAS 1804798-01-3)
- 2-(Difluoromethyl)-4-hydroxy-3-(trifluoromethoxy)pyridine-6-acetic acid (CAS 1804837-46-4)
- 2-(4-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1804837-61-3)
- 4-(Difluoromethyl)-3-methoxy-6-(trifluoromethoxy)picolinic acid (CAS 1804953-96-5)
- 2-(Difluoromethyl)-5-methoxy-3-(trifluoromethoxy)pyridine-6-carboxylic acid (CAS 1805099-78-8)
Recommended Standards
- 2-(4-(Difluoromethyl)-3-hydroxy-6-(trifluoromethoxy)pyridin-2-yl)acetic acid (CAS 1806194-94-4)
- 4-(Difluoromethyl)-2-methoxy-6-(trifluoromethoxy)nicotinic acid (CAS 1806255-30-0)
- 2-(Difluoromethyl)-6-hydroxy-5-(trifluoromethoxy)pyridine-3-acetic acid (CAS 1806160-69-9)
- 4-(Difluoromethyl)-5-methoxy-2-(trifluoromethoxy)nicotinic acid (CAS 1806255-39-9)
- 2-(5-Chloro-2-methyl-4-nitrophenyl)-3,4-dihydronaphthalen-1(2H)-one (CAS 1451449-44-7)
- 3-(3-Nitrobenzoyl)phenyl acetate (CAS 890099-77-1)
- 3-Ethoxy-5-(methylthio)thiophene-2-carboxylic acid (CAS 1774902-59-8)
- 4-Methyl-2-(1H-pyrrol-1-yl)pentanoic acid (CAS 53623-79-3)
- 2-Formylbenzene-1,4-disulfonic acid (CAS 730912-46-6)
- 215121-47-4 10b-(2-Methylbut-3-en-2-yl)-3-(2-methylpropyl)-6,10b,11,11a-tetrahydro-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione DTXSID30679783 (CAS 215121-47-4)
- tert-Butyl (3-fluoro-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate (CAS 2388488-33-1)
- 1-(4-(Trifluoromethyl)benzyl)pyrrolidin-2-one (CAS 1353087-69-0)
- Tert-butyl 3-(aminooxy)pyrrolidine-1-carboxylate (CAS 186202-36-8)
- Tirzepatide(sodium salt) (CAS 2023788-19-2(free base))
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