1-(4-(Trifluoromethyl)benzyl)pyrrolidin-2-one CAS 1353087-69-0
| CAS No. | 1353087-69-0 |
| Molecular Formula | C12H12F3NO |
| Molecular Weight | 243.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(4-(Trifluoromethyl)benzyl)pyrrolidin-2-one (CAS 1353087-69-0) is a high-purity analytical reference standard with the molecular formula C12H12F3NO and a molecular weight of 243.22 g/mol.
Structurally, 1-(4-(Trifluoromethyl)benzyl)pyrrolidin-2-one (C12H12F3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 243.22 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(4-(Trifluoromethyl)benzyl)pyrrolidin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12F3NO |
| Molecular Weight | 243.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 5-(Trifluoromethyl)-2H-spiro[benzofuran-3,3'-pyrrolidine] (CAS 1047657-74-8)
- 5-(2-(Trifluoromethyl)phenoxy)pentanenitrile (CAS 1303743-39-6)
- 5-(3-(Trifluoromethyl)phenoxy)pentanenitrile (CAS 1307520-98-4)
- 3-(4-(Trifluoromethyl)benzyl)pyrrolidin-2-one (CAS 1350989-17-1)
- 1-(3-(Trifluoromethyl)phenyl)piperidin-4-one (CAS 147378-74-3)
- 4-Methyl-4-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one (CAS 1488856-28-5)
- 4-Methyl-4-(4-(trifluoromethyl)phenyl)pyrrolidin-2-one (CAS 1494528-00-5)
- 1-(2-(Trifluoromethyl)phenyl)piperidin-4-one (CAS 821792-43-2)
Recommended Standards
- 1365963-46-7 2-[2-(1,2,4-Oxadiazol-3-yl)ethyl]-1H-isoindole-1,3(2H)-dione MFCD22056554 (CAS 1365963-46-7)
- 4,4-Dimethyl-2-(2,4,5-trifluoro-3-methylphenyl)-4,5-dihydrooxazole (CAS 132630-83-2)
- 2-(Pyrrolidin-1-yl)-4-(trifluoromethyl)benzaldehyde, 97% (CAS 1374603-97-0)
- tert-Butyl(1,1,1-trifluoro-4-hydroxybutan-2-yl)carbamate (CAS 1402429-03-1)
- 9-Cyclopropyl-8-(3-methoxyphenyl)-1H-purine-6(9H)-thione (CAS 682345-28-4)
- 2-Chloro-1-(3-((cyclopropylmethyl)amino)pyrrolidin-1-yl)ethanone (CAS 1353947-23-5)
- Methyl 5,6-dimethoxy-1H-indole-1-carboxylate (CAS 77468-98-5)
- (2,3,5,6-Tetramethyl-1,4-phenylene)dimethanamine (CAS 32321-30-5)
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- 4-bromo-6-[(4-methoxyphenyl)methoxy]-2-methylpyrimidine (CAS 1715298-06-8)
- GLP-1(7-37) (CAS 106612-94-6)
- 3-((4-Methoxybenzyl)oxy)azetidine (CAS 1219980-02-5)
- 1-Phenyl-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepine (CAS 60794-92-5)
- Des-Ile12-Aib13-Tirzepatide (CAS CATO-CPTD788960)
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