2-Cyano-6-methoxynicotinic acid CAS 1806309-01-2
| CAS No. | 1806309-01-2 |
| Molecular Formula | C8H6N2O3 |
| Molecular Weight | 178.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Cyano-6-methoxynicotinic acid.
2-Cyano-6-methoxynicotinic acid (CAS 1806309-01-2) is a high-purity analytical reference standard with the molecular formula C8H6N2O3 and a molecular weight of 178.14 g/mol.
2-Cyano-6-methoxynicotinic acid (C8H6N2O3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6N2O3 |
| Molecular Weight | 178.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 2 |
Related Cyano Standards
- 5-Cyano-2-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (CAS 101184-51-4)
- 5-Cyano-6-methoxypicolinic acid (CAS 104969-32-6)
- 3-Cyano-5-methoxyisonicotinic acid (CAS 1138444-09-3)
- 5-Cyano-6-methoxynicotinic acid (CAS 1258972-98-3)
- 5-Cyano-6-hydroxy-4-methylnicotinic acid (CAS 1306739-55-8)
- 5-cyano-3-methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid (CAS 1367865-25-5)
- 2-(6-Cyano-4-hydroxypyridin-2-yl)acetic acid (CAS 1393539-64-4)
- 2-Cyano-6-methoxyisonicotinic Acid (CAS 1393567-37-7)
Recommended Standards
- 4-Cyano-2,6-difluorophenylacetonitrile (CAS 1805669-29-7)
- 5-hydroxy-1,3-benzoxazole-2-carboxamide (CAS 1806524-82-2)
- 5-Cyano-4-methoxypicolinic acid (CAS 1805485-28-2)
- 4,5-Dihydroxy-1,3-bis(hydroxymethyl)imidazolidin-2-one (CAS 1854-26-8)
- Ethyl 2-(2,5-dimethylphenyl)acetate (CAS 58358-37-5)
- Ethyl 1-(3-bromophenyl)-4-methoxy-6-oxo-1,6-dihydropyridazine-3-carboxylate (CAS 886952-54-1)
- 4-Methoxy-N-((6,7,8,9-tetrahydro-5h-[1,2,4]triazolo[4,3-a]azepin-3-yl)methyl)aniline (CAS 397291-55-3)
- Pentafluoroethyl phenyl ketone (CAS 394-52-5)
- 2-[4-(4-fluorophenyl)pyrazol-1-yl]acetic acid (CAS 1206997-40-1)
- Benzo[c][1,2,5]thiadiazol-5-yl(7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)methanone (CAS 1797142-46-1)
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