3,5-Dichloro-4-(difluoromethoxy)benzotrifluoride CAS 1806352-78-2
| CAS No. | 1806352-78-2 |
| Molecular Formula | C8H3Cl2F5O |
| Molecular Weight | 281.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 281.01 g/mol gives 3,5-Dichloro-4-(difluoromethoxy)benzotrifluoride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3,5-Dichloro-4-(difluoromethoxy)benzotrifluoride (CAS 1806352-78-2) is a high-purity analytical reference standard with the molecular formula C8H3Cl2F5O and a molecular weight of 281.01 g/mol.
3,5-Dichloro-4-(difluoromethoxy)benzotrifluoride (C8H3Cl2F5O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H3Cl2F5O |
| Molecular Weight | 281.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
Related Dichloro Standards
- (2,6-Dichloro-3,5-difluoro-4-(trifluoromethyl)phenyl)hydrazine (CAS 111234-64-1)
- 3,4-Dichloro-2-(difluoromethoxy)benzotrifluoride (CAS 1803713-27-0)
- 3,4-Dichloro-5-(difluoromethoxy)benzotrifluoride (CAS 1803713-34-9)
- 2,4-Dichloro-3-(difluoromethoxy)benzotrifluoride (CAS 1803788-83-1)
- 2,6-Dichloro-3-(difluoromethoxy)benzotrifluoride (CAS 1803788-96-6)
- 2,3-Dichloro-6-(difluoromethoxy)benzotrifluoride (CAS 1803831-47-1)
- 2,3-Dichloro-5-(difluoromethoxy)benzotrifluoride (CAS 1804882-88-9)
- 2,4-Dichloro-5-(difluoromethoxy)benzotrifluoride (CAS 1804883-02-0)
Recommended Standards
- 2,4-Dichloro-6-(difluoromethoxy)benzotrifluoride (CAS 1806349-66-5)
- 6-Bromo-5-(difluoromethyl)-4-nitropicolinaldehyde (CAS 1806858-09-2)
- 3,6-Dichloro-2-(difluoromethoxy)benzotrifluoride (CAS 1806322-21-3)
- 6-Bromo-3-(difluoromethyl)-5-nitropicolinaldehyde (CAS 1806858-11-6)
- 1-Chlorophospholane 1-oxide (CAS 30148-59-5)
- 3-Hydroxy-3-(4'-methoxy-3'-sulfonamidophenyl)-2-propylamine, Hydrochloride 5-(2-Amino-1-hydroxypropyl)-2-methoxy-benzenesulfonamide Hydrochloride 86225-64-1 (CAS 86225-64-1)
- (±)-Isoborneol (CAS 124-76-5)
- 1-Allyl-4-(naphthalen-1-yl)-1,4-dihydropyrazine-2,3-dione (CAS 898409-58-0)
- Methyl 6-chloro-5-hydroxy-2-methoxynicotinate (CAS 2923011-07-6)
- 7-Benzyl-4-chloro-2-methyl-5H-pyrrolo[3,2-d]pyrimidine (CAS 1392817-33-2)
- 2-(Benzyloxy)-4-methylaniline hydrochloride (CAS 142769-31-1)
- 9-Methyl-6-((4-nitrophenyl)thio)-9H-purine (CAS 51302-03-5)
- Nefopam Impurity 33 (CAS CATO-C4X-283733)
- 149471-11-4 Neuropeptide DF2 L-Phenylalaninamide, L-alpha-aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl- Asp-arg-asn-phe-leu-arg-phe-NH2 Aspartyl-arginyl-asparaginyl-phenylalanyl-leucyl-arginyl-phenylalaninamide L-alpha-Aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl-L-phenylalaninamide DF(2) Neuropeptide Drnflrfamide (CAS 149471-11-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com