4-(Difluoromethyl)-5,6-dihydroxypyridine-3-sulfonyl chloride CAS 1806825-73-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethyl)-5,6-dihydroxypyridine-3-sulfonyl chloride.

4-(Difluoromethyl)-5,6-dihydroxypyridine-3-sulfonyl chloride (CAS 1806825-73-9) is a high-purity analytical reference standard with the molecular formula C6H4ClF2NO4S and a molecular weight of 259.62 g/mol.

The molecular framework of 4-(Difluoromethyl)-5,6-dihydroxypyridine-3-sulfonyl chloride (C6H4ClF2NO4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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