4-Bromo-2-(difluoromethyl)-5-fluoronicotinic acid CAS 1806832-99-4
| CAS No. | 1806832-99-4 |
| Molecular Formula | C7H3BrF3NO2 |
| Molecular Weight | 270.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Bromo-2-(difluoromethyl)-5-fluoronicotinic acid (CAS 1806832-99-4), molecular formula C7H3BrF3NO2 and molecular weight 270.00 g/mol, is a CATO reference standard with documented purity and traceability.
4-Bromo-2-(difluoromethyl)-5-fluoronicotinic acid (C7H3BrF3NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromo-2-(difluoromethyl)-5-fluoronicotinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3BrF3NO2 |
| Molecular Weight | 270.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
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- 6-Bromo-4-(trifluoromethyl)nicotinic acid (CAS 1060805-50-6)
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- 1-Bromo-3-nitro-2-(trifluoromethyl)benzene (CAS 1192548-07-4)
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Recommended Standards
- 6-Bromo-5-(difluoromethyl)-2-fluoronicotinic acid (CAS 1806831-97-9)
- 4-Bromo-5-(difluoromethyl)-3-fluoropicolinic acid (CAS 1806833-14-6)
- 4-Bromo-6-(difluoromethyl)-2-fluoronicotinic acid (CAS 1806060-20-7)
- 2-Bromo-5-(difluoromethyl)-3-fluoroisonicotinic acid (CAS 1806905-50-9)
- 5-Bromo-3-methyl-6-phenoxypyrimidine-2,4(1H,3H)-dione (CAS 81077-93-2)
- 3-(2-Iodophenyl)propan-1-ol (CAS 26059-41-6)
- (5-(4-Methyl-2-nitrophenyl)furan-2-yl)methanol (CAS 875001-60-8)
- (Z)-[(4-Bromophenyl)[2-(4-chlorophenyl)cyclopropyl]methylidene][(2,4-dichlorophenyl)methoxy]amine (CAS 338749-09-0)
- (S)-N,N,N-Trimethyl-4-(2-methyl-5-oxopyrrolidin-1-yl)but-2-yn-1-aminium iodide (CAS 98612-65-8)
- 1-(2-Chlorobenzyl)-3-methyl-6-phenyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid (CAS 1011399-97-5)
- 1-(3,4-Diethoxyphenyl)-2-methylpropan-1-amine (CAS 874623-47-9)
- 4-(Bromomethyl)phenyl propionate (CAS 124254-95-1)
- 3-Ethyl-2-oxopyrrolidine-3-carboxylic acid (CAS 1520548-29-1)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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