4-Cyano-2-(difluoromethyl)-6-hydroxynicotinoyl chloride CAS 1806948-74-2
| CAS No. | 1806948-74-2 |
| Molecular Formula | C8H3ClF2N2O2 |
| Molecular Weight | 232.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Cyano-2-(difluoromethyl)-6-hydroxynicotinoyl chloride is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Cyano-2-(difluoromethyl)-6-hydroxynicotinoyl chloride (CAS 1806948-74-2), a certified reference material (molecular formula C8H3ClF2N2O2, MW 232.57 g/mol) for analytical method development and quality control.
Structurally, 4-Cyano-2-(difluoromethyl)-6-hydroxynicotinoyl chloride (C8H3ClF2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 232.57 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Cyano-2-(difluoromethyl)-6-hydroxynicotinoyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF2N2O2 |
| Molecular Weight | 232.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Cyano Standards
- 4-Cyano-5-(difluoromethyl)-6-hydroxypicolinoyl chloride (CAS 1805423-63-5)
- 4-Cyano-3-(difluoromethyl)-5-hydroxypyridine-2-carbonyl chloride (CAS 1807094-13-8)
- 6-Cyano-4-methoxypyridine-2-sulfonyl chloride (CAS 1393538-88-9)
- 2-Cyano-6-methoxypyridine-4-sulfonyl chloride (CAS 1393541-01-9)
- 4-Cyano-6-methoxypyridine-2-sulfonyl chloride (CAS 1393548-00-9)
- 5-Cyano-2-methoxypyridine-3-sulfonyl chloride (CAS 2505372-52-9)
- N-(5-cyano-2-(methylthio)phenyl)cyclopropanecarboxamide (CAS 303147-48-0)
- Ethyl 2-[[cyano(p-tolyl)methyl]amino]acetate (CAS 1018554-67-0)
Recommended Standards
- 6-Chloro-2-cyano-5-(difluoromethyl)nicotinic acid (CAS 1805970-81-3)
- 6-Chloro-5-cyano-4-(difluoromethyl)picolinic acid (CAS 1806975-14-3)
- 4-Chloro-6-cyano-3-(difluoromethyl)pyridine-2-carboxylic acid (CAS 1805396-30-8)
- 6-Chloro-2,2-difluoro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]imidazole (CAS 188028-13-9)
- 3-Isopropyl-5-(methylthio)-1-phenyl-1H-pyrazole (CAS 871110-03-1)
- 4-Hydroxy-5-isopropyl-6-methyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester (CAS 100371-18-4)
- (1,4,7,10,13,16-Hexaoxacyclooctadecan-2-yl)methanethiol (CAS 89566-62-1)
- 3-methyl-3-propylpiperazin-2-one (CAS 1239783-56-2)
- Isoquercitrin (CAS 482-35-9)
- 2-((Methylsulfonyl)thio)acetic acid (CAS 13700-15-7)
- 2255-94-9 5-Chloro-6-methyl-2,1,3-benzoselenadiazole DTXSID10566041 (CAS 2255-94-9)
- 4-(6-Methoxypyridazin-3-yl)aniline (CAS 1105195-18-3)
- Benzyl 4-(((2-aminoethyl)thio)methyl)piperidine-1-carboxylate (CAS 1353959-55-3)
- Hexapeptide-9 (CAS 1228371-11-6)
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