4-Cyano-2-(difluoromethyl)-3-hydroxypyridine-6-carboxaldehyde CAS 1806949-40-5
| CAS No. | 1806949-40-5 |
| Molecular Formula | C8H4F2N2O2 |
| Molecular Weight | 198.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Cyano-2-(difluoromethyl)-3-hydroxypyridine-6-carboxaldehyde.
CATO supplies 4-Cyano-2-(difluoromethyl)-3-hydroxypyridine-6-carboxaldehyde (CAS 1806949-40-5), a certified reference material (molecular formula C8H4F2N2O2, MW 198.13 g/mol) for analytical method development and quality control.
The molecular framework of 4-Cyano-2-(difluoromethyl)-3-hydroxypyridine-6-carboxaldehyde (C8H4F2N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F2N2O2 |
| Molecular Weight | 198.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Cyano Standards
- 5-Cyano-2-(difluoromethyl)nicotinic acid (CAS 1513851-02-9)
- 5-Cyano-3-(difluoromethyl)picolinic acid (CAS 1628915-70-7)
- 2-Cyano-6-(difluoromethyl)isonicotinic acid (CAS 1805647-65-7)
- 4-Cyano-5-(difluoromethyl)picolinic acid (CAS 1805666-49-2)
- 4-Cyano-3-(difluoromethyl)-2-hydroxypyridine-6-carboxaldehyde (CAS 1805921-06-5)
- 4-Cyano-3-(difluoromethyl)-2-methoxy-5-methylpyridine (CAS 1807073-85-3)
- 4-Cyano-3-(difluoromethyl)-2-methylpyridine-6-methanol (CAS 1807160-60-6)
- 2-Cyano-6-hydroxybenzenesulfonamide (CAS 1243283-87-5)
Recommended Standards
- 3-(Difluoromethyl)-4-formyl-6-hydroxypicolinonitrile (CAS 1806876-34-5)
- 3-(Difluoromethyl)-6-formyl-4-hydroxypicolinonitrile (CAS 1806986-87-7)
- 2-(2,5-Difluoro-3-nitrophenyl)acetonitrile (CAS 1806352-38-4)
- Methyl 4-hydroxy-6-nitropicolinate (CAS 1807064-04-5)
- 4-(4-(Pyrrolidin-1-ylsulfonyl)phenyl)nicotinic acid (CAS 1261940-00-4)
- 4-Amino-1,1,1-trifluoro-2-(trifluoromethyl)butan-2-ol hydrochloride (CAS 2193061-99-1)
- 2-Fluoro-N-(2-iodophenyl)benzamide (CAS 326902-16-3)
- 2-(2-Methyl-1H-indol-3-yl)-2-oxoacetamide (CAS 1080-83-7)
- 3-((1-(Tetrahydrofuran-2-yl)ethyl)amino)thietane 1,1-dioxide (CAS 1875255-98-3)
- (2R,3S,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl methyl diiSopropylphosphoramidite (CAS 84416-83-1)
- Methyl 3-fluoro-4-methoxy-2-(methylthio)benzoate (CAS 2635937-28-7)
- 3-Isopropylpyridine-2-sulfonamide (CAS 2089377-22-8)
- 2-(4-(Difluoromethyl)-5-hydroxy-6-methylpyridin-2-yl)acetonitrile (CAS 1805255-14-4)
- Semaglutide Impurity 131 (CAS 2618647-80-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com