6-Chloro-4-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde CAS 1806985-07-8
| CAS No. | 1806985-07-8 |
| Molecular Formula | C8H3ClF5NO |
| Molecular Weight | 259.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Chloro-4-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde (C8H3ClF5NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
6-Chloro-4-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde (CAS 1806985-07-8), molecular formula C8H3ClF5NO and molecular weight 259.56 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Chloro-4-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3ClF5NO |
| Molecular Weight | 259.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-5-(difluoromethyl)-2-(trifluoromethyl)nicotinaldehyde (CAS 1804371-43-4)
- 2-Chloro-5-(difluoromethyl)-3-(trifluoromethyl)isonicotinaldehyde (CAS 1805082-14-7)
- 6-Chloro-3-(difluoromethyl)-5-(trifluoromethyl)picolinaldehyde (CAS 1805369-27-0)
- 2-Chloro-6-(difluoromethyl)-4-(trifluoromethyl)nicotinaldehyde (CAS 1805369-36-1)
- 4-Chloro-2-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde (CAS 1805369-60-1)
- 2-Chloro-4-(difluoromethyl)-6-(trifluoromethyl)nicotinaldehyde (CAS 1805423-13-5)
- 4-Chloro-6-(difluoromethyl)-5-(trifluoromethyl)picolinaldehyde (CAS 1806071-72-6)
- 4-Chloro-3-(difluoromethyl)-5-(trifluoromethyl)picolinaldehyde (CAS 1806071-85-1)
Recommended Standards
- 6-Chloro-4-(difluoromethyl)-5-(trifluoromethyl)picolinaldehyde (CAS 1806903-71-8)
- 2-Chloro-5-(difluoromethyl)-6-(trifluoromethyl)nicotinaldehyde (CAS 1806985-13-6)
- 2-Chloro-6-(difluoromethyl)-3-(trifluoromethyl)isonicotinaldehyde (CAS 1806875-53-5)
- 6-Chloro-5-(difluoromethyl)-2-(trifluoromethyl)nicotinaldehyde (CAS 1807152-09-5)
- 1-(2-(Chloromethyl)-6-fluoropyridin-4-yl)ethan-1-one (CAS 1393568-36-9)
- 1-Benzyl-1-[4-(trifluoromethyl)benzyl]hydrazine dihydrochloride (CAS 237403-61-1)
- 3-methyl-5-[4-(propan-2-yl)piperazin-1-yl]aniline dihydrochloride (CAS 1803584-07-7)
- 2-Methyl-1H-benzimidazol-5-ol hydrobromide (CAS 1417568-15-0)
- (S)-1-(3,4-dimethylphenyl)but-3-en-1-amine (CAS 1269929-27-2)
- 5-Fluoro-1-((2S,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 2145-71-3)
- Vericiguat Impurity 66 (CAS CATO-C4X-289666)
- 2-(4-(2-Aminoethyl)phenyl)-N,N-diethylacetamide (CAS 885270-64-4)
- Methyl 2-(4-cyano-2-fluorophenyl)acetate (CAS 942282-44-2)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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