Vericiguat Impurity 66 CAS CATO-C4X-289666
| CAS No. | CATO-C4X-289666 |
| Molecular Formula | C21H20F2N8O2 |
| Molecular Weight | 454.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Vericiguat Impurity 66 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Vericiguat Impurity 66 (CAS CATO-C4X-289666), a pharmacopoeial impurity reference standard (molecular formula C21H20F2N8O2, MW 454.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Vericiguat Impurity 66 (C21H20F2N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Vericiguat Impurity 66 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H20F2N8O2 |
| Molecular Weight | 454.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Vericiguat Standards
- Vericiguat Impurity 13 (CAS CATO-C4X-289613)
- Vericiguat Impurity 94 (CAS CATO-C4X-289694)
- Vericiguat Impurity 58 (CAS CATO-C4X-289658)
- Vericiguat Impurity 36 (CAS CATO-C4X-289636)
- Vericiguat Impurity 70 (CAS CATO-C4X-289670)
- Vericiguat Impurity 11 (CAS 1350653-29-0)
- Vericiguat Impurity 23 (CAS CATO-C4X-289623)
- Vericiguat Impurity 28 (CAS CATO-C4X-289628)
Recommended Standards
- Z-Asp(OSu)-OBzl (CAS 108325-86-6)
- Eltrombopag Impurity 45 (CAS CATO-C4X-119845)
- 1-(Benzofuro[3,2-d]pyrimidin-4-yl)-N-(2-(trifluoromethyl)benzyl)piperidine-3-carboxamide (CAS 1115900-28-1)
- Z-Asp(OBzl)-OSu (CAS 61464-33-3)
- Acalabrutinib Impurity 29 (CAS CATO-C4X-305529)
- Pemetrexed EP Impurity B Tetrasodium salt (CAS 1802552-04-0 (free base))
- Mirabegron impurity 97 (CAS CATO-C4X-103297)
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- 5-(3-Bromo-2-methylpropyl)-1-methyl-1h-1,2,4-triazole (CAS 1492232-70-8)
- 5-(4-methylbenzoyl)-3-thiatricyclo[5.2.1.0^{2,6}]deca-2(6),4-dien-4-amine (CAS 1803586-19-7)
- (S)-4-Aminopentanoic acid (CAS 1558-59-4)
- 1-TERT-BUTYL 2-METHYL 5,6-DIHYDROPYRIDINE-1,2(4H)-DICARBOXYLATE (CAS 155905-80-9)
- (3AR,7aR)-3-isopropyl-3a,4,7,7a-tetrahydrobenzo[d]isoxazole (CAS 175433-95-1)
- Immunstimulating Peptide, human (CAS 94773-24-7)
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