6-Bromo-4-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile CAS 1806997-80-7
| CAS No. | 1806997-80-7 |
| Molecular Formula | C8H5BrF2N2O |
| Molecular Weight | 263.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-Bromo-4-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile (CAS 1806997-80-7), molecular formula C8H5BrF2N2O and molecular weight 263.04 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Bromo-4-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile (C8H5BrF2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Bromo-4-(difluoromethyl)-5-(hydroxymethyl)picolinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5BrF2N2O |
| Molecular Weight | 263.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 2-Bromo-5-(difluoromethoxy)-1H-benzo[d]imidazole (CAS 1803895-85-3)
- 2-Bromo-7-(difluoromethoxy)-1H-benzo[d]imidazole (CAS 1803896-63-0)
- 4-Bromo-6-(difluoromethoxy)-1H-benzimidazole (CAS 1804051-46-4)
- 6-Bromo-5-(difluoromethyl)-3-methoxypicolinonitrile (CAS 1804460-27-2)
- 2-Bromo-5-(difluoromethyl)-6-(hydroxymethyl)nicotinonitrile (CAS 1804463-18-0)
- 2-(2-Bromo-5-(difluoromethyl)-4-hydroxypyridin-3-yl)acetonitrile (CAS 1804660-56-7)
- 2-(4-Bromo-6-(difluoromethyl)-3-hydroxypyridin-2-yl)acetonitrile (CAS 1804660-97-6)
- 6-Bromo-4-(difluoromethyl)-5-(hydroxymethyl)nicotinonitrile (CAS 1804841-65-3)
Recommended Standards
- 2-Bromo-3-(difluoromethyl)-6-(hydroxymethyl)isonicotinonitrile (CAS 1806997-69-2)
- 4-Bromo-3-cyano-2-(difluoromethyl)pyridine-5-methanol (CAS 1806998-35-5)
- 4-Bromo-2-cyano-5-(difluoromethyl)-3-methoxypyridine (CAS 1806994-13-7)
- 2-(Bromomethyl)-6-cyano-4-(difluoromethyl)-3-hydroxypyridine (CAS 1807022-96-3)
- Ethyl 2-(3'-bromo-[1,1'-biphenyl]-4-yl)acetate (CAS 910330-18-6)
- 4-((3-Bromopropyl)amino)-5-chloropyridazin-3(2H)-one (CAS 252031-70-2)
- 6-(Difluoromethyl)-5-methylpyridin-2-amine (CAS 1804653-03-9)
- 4-Bromo-2-nitrobenzene-1-sulfonyl chloride (CAS 89465-98-5)
- (Butan-2-yl)(2-phenylpropyl)amine hydrochloride (CAS 1158592-60-9)
- Miglitol Impurity C (CAS 1550201-56-3)
- 2-Propylcyclohexanone (CAS 94-65-5)
- 2-Amino-3-methoxy-5-methylbenzoic acid (CAS 80389-40-8)
- 4-(2-Hydroxyphenyl)-1H-pyrrole-3-carbonitrile (CAS 87388-25-8)
- Tirzepatide Impurity 57 (CAS CATO-C4X-324057)
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