4-(Chloromethyl)-5-(difluoromethyl)-6-iodonicotinic acid CAS 1807014-59-0
| CAS No. | 1807014-59-0 |
| Molecular Formula | C8H5ClF2INO2 |
| Molecular Weight | 347.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Chloromethyl)-5-(difluoromethyl)-6-iodonicotinic acid (C8H5ClF2INO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 4-(Chloromethyl)-5-(difluoromethyl)-6-iodonicotinic acid (CAS 1807014-59-0), a certified reference material (molecular formula C8H5ClF2INO2, MW 347.49 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2INO2 |
| Molecular Weight | 347.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl/I-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 2-(Chloromethyl)-3-(difluoromethyl)-4-iodopyridine-5-carboxylic acid (CAS 1805067-69-9)
- 2-(Chloromethyl)-5-(difluoromethyl)-3-iodopyridine-4-carboxylic acid (CAS 1805067-76-8)
- 2-(Chloromethyl)-5-(difluoromethyl)-6-iodopyridine-3-carboxylic acid (CAS 1805067-82-6)
- 4-(Chloromethyl)-2-(difluoromethyl)-5-iodonicotinic acid (CAS 1805068-11-4)
- 2-(Chloromethyl)-6-(difluoromethyl)-3-iodopyridine-4-carboxylic acid (CAS 1805143-08-1)
- 2-(Chloromethyl)-3-(difluoromethyl)-6-iodopyridine-4-carboxylic acid (CAS 1805261-57-7)
- 2-(Chloromethyl)-4-(difluoromethyl)-3-iodopyridine-5-carboxylic acid (CAS 1805549-68-1)
- 4-(Chloromethyl)-6-(difluoromethyl)-2-iodonicotinic acid (CAS 1805549-82-9)
Recommended Standards
- 2-(Chloromethyl)-5-(difluoromethyl)-3-iodopyridine-6-carboxylic acid (CAS 1807014-39-6)
- 4-(Difluoromethyl)-5-iodo-6-methoxynicotinoyl chloride (CAS 1807015-28-6)
- 2-(Chloromethyl)-4-(difluoromethyl)-5-iodopyridine-3-carboxylic acid (CAS 1807014-32-9)
- 2-(4-Chloro-2-(difluoromethyl)-6-iodopyridin-3-yl)acetic acid (CAS 1807074-63-0)
- (2-((4-Benzylphenyl)dimethylsilyl)phenyl)methanol (CAS 1398044-23-9)
- 2-(3,4,5-Trimethoxyphenyl)acetohydrazide (CAS 34547-25-6)
- 5-Acetylpyrazine-2-carboxamide (CAS 147425-79-4)
- 5-Chloro-1-methyl-1H-indole (CAS 112398-75-1)
- Cobalt(II)-EDTA (CAS 14931-83-0)
- 2-chloro-1-methyl-1H-1,3-benzodiazol-7-ol (CAS 1781526-78-0)
- 1-(5,7-Dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)ethan-1-one (CAS 13925-33-2)
- 2-(4-Fluorophenyl)-2'-oxospiro[cyclopropane-1,3'-indoline]-5'-carboxylic acid (CAS 1708269-21-9)
- 2-(Trimethylsilyl)-1,3-dithiane (CAS 13411-42-2)
- D-allo-Thr5-Semaglutide (CAS CATO-C4X-2226243)
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