2-Iodopyrimidin-4-amine CAS 1807180-37-5
| CAS No. | 1807180-37-5 |
| Molecular Formula | C4H4IN3 |
| Molecular Weight | 221.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Iodopyrimidin-4-amine is closely related to a nitrile group, iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Iodopyrimidin-4-amine (CAS 1807180-37-5), molecular formula C4H4IN3 and molecular weight 221.00 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Iodopyrimidin-4-amine (C4H4IN3) is characterized by a nitrile group, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Iodopyrimidin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4H4IN3 |
| Molecular Weight | 221.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 3 |
Related Iodopyrimidin Standards
- 2-Iodopyrimidin-5-amine (CAS 1378847-85-8)
- 4-Iodopyrimidin-5-amine (CAS 942067-98-3)
- 5-iodopyrimidin-4-amine (CAS 91416-96-5)
- 6-Iodopyrimidin-4-amine (CAS 53557-69-0)
- 4-Iodopyrimidin-5-ol (CAS 161286-33-5)
- 5-Iodopyrimidin-2(1H)-one (CAS 79387-69-2)
- 5-Iodopyrimidin-4-ol (CAS 4349-07-9)
- (2-Iodopyrimidin-4-yl)methanol (CAS 2280988-98-7)
Recommended Standards
- 6-Iodopyridin-2(1H)-one (CAS 173442-31-4)
- 3-Iodopyridin-2-ol (CAS 1822890-83-4)
- 2-Bromo-3,4-difluorobenzaldehyde (CAS 1578156-21-4)
- 3-Hydroxy-4-iodopyridine (CAS 188057-20-7)
- 4-(4-BRomo-3-methoxyphenoxy)piperidine (CAS 2140326-57-2)
- (1-Methylindolin-6-yl)boronic acid (CAS 1551417-42-5)
- 4-(1H-1,2,4-Triazol-1-yl)piperidine (CAS 158655-26-6)
- 2-Methoxypropanehydrazide (CAS 887029-63-2)
- N-(4-methylpentan-2-yl)-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 1036561-08-6)
- 2-Ethynyl-1,3-difluoro-5-methoxybenzene (CAS 1857323-46-6)
- 1-Boc-4-(Cbz-Aminomethylcarbonyl)piperazine (CAS 353495-62-2)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-3-ethoxy-4-[(1E)-({[4-(trifluoromethyl)phenyl]methoxy}imino)methyl]-1H-pyrazol-5-ol (CAS 324009-23-6)
- Vonoprazan Fumarate Impurity 119 (CAS CATO-C4X-1020119)
- Xenopsin-Related Peptide 2 (XP-2) (H-9340.0005) (CAS 117442-29-2)
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