Darolutamide Impurity 48 CAS 1818028-57-7
| CAS No. | 1818028-57-7 |
| Molecular Formula | C10H6ClN3 |
| Molecular Weight | 203.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Darolutamide Impurity 48 (CAS 1818028-57-7, C10H6ClN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H6ClN3, Darolutamide Impurity 48 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 203.63 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Darolutamide Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H6ClN3 |
| Molecular Weight | 203.63 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Darolutamide Standards
- Darolutamide impurity 3 (CAS 1297537-37-1)
- Darolutamide Impurity 50 (CAS CATO-C4X-310650)
- Darolutamide Impurity 51 (CAS CATO-C4X-310651)
- Darolutamide Impurity 32 (CAS CATO-C4X-310632)
- Darolutamide Impurity 1 (CAS CATO-C4X-31061)
- Darolutamide Impurity 36 (CAS CATO-C4X-310636)
- Darolutamide Impurity 49 (CAS CATO-C4X-310649)
- Darolutamide Impurity 22 (CAS CATO-C4X-310622)
Recommended Standards
- (3-Chloro-4-ethoxy-5-fluorophenyl)methanamine (CAS 1017779-02-0)
- 7-chloro-1H,2H,3H,4H-pyrido[2,3-d]pyrimidine-2,4-dione (CAS 938443-19-7)
- 2-(2-Chloro-6-fluorophenyl)-2-(methylamino)ethanol (CAS 1178961-04-0)
- 7-Amino-3-chloroquinoline-8-carbonitrile (CAS 88362-40-7)
- Amiodarone Impurity 21 (CAS CATO-C4X-142521)
- Metoclopramide impurity 82 (CAS CATO-C4X-141582)
- Atrasentan Impurity 81 (CAS 1058552-23-0)
- N-(2-chloroethyl)cyclohexanamine (CAS 21635-10-9)
- N-Methylaminophthalimide (CAS 74420-78-3)
- 3-((4-(Trifluoromethyl)pyrimidin-2-yl)amino)propane-1-sulfonamide (CAS 1241207-68-0)
- N,N,2-Trimethyl-3-oxobutanamide (CAS 69946-47-0)
- 6-Cyano-5-(difluoromethyl)-4-hydroxypyridine-2-sulfonamide (CAS 1806842-96-5)
- 2-Amino-4,5-dimethoxybenzaldehyde (CAS 22608-87-3)
- Semaglutide impurity 46 (CAS CATO-C4X-222646)
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