Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid CAS 181953-60-6
| CAS No. | 181953-60-6 |
| Molecular Formula | C25H20F3NO4 |
| Molecular Weight | 455.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid (CAS 181953-60-6), molecular formula C25H20F3NO4 and molecular weight 455.43 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid (C25H20F3NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H20F3NO4 |
| Molecular Weight | 455.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fmoc Standards
- Fmoc-(R)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid (CAS 517905-87-2)
- Fmoc-(R)-3-Amino-3-(4-trifluoromethylphenyl)-propionic acid (CAS 517905-88-3)
- Fmoc-(RS)-3-amino-3-(4-trifluoromethylphenyl)-propionic acid (CAS 728919-94-6)
- Fmoc-(S)-3-amino-3-(2-trifluoromethylphenyl)-propionic acid (CAS 507472-19-7)
- Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionic acid (CAS 507472-20-0)
- Fmoc-(S)-3-Amino-3-(4-trifluoromethylphenyl)-propionic acid (CAS 507472-21-1)
- Fmoc-2-(trifluoromethyl)-L-phenylalanine (CAS 352523-16-1)
- Fmoc-D-Phe(4-CF3)-OH (CAS 238742-88-6)
Recommended Standards
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- (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid (CAS 517905-86-1)
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