Methyl 2-chloro-4-[4-(trifluoromethoxy)phenyl]benzoate CAS 1820675-34-0
| CAS No. | 1820675-34-0 |
| Molecular Formula | C15H10ClF3O3 |
| Molecular Weight | 330.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl 2-chloro-4-[4-(trifluoromethoxy)phenyl]benzoate (C15H10ClF3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Methyl 2-chloro-4-[4-(trifluoromethoxy)phenyl]benzoate (CAS 1820675-34-0), a certified reference material (molecular formula C15H10ClF3O3, MW 330.69 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10ClF3O3 |
| Molecular Weight | 330.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
Related Methyl Standards
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- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methylnicotinohydrazide (CAS 1024115-40-9)
- 4-((4-Chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-methylbenzamide (CAS 1073160-19-6)
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- 8-Chloro-2-(2,2,2-trifluoroacetyl)-1,3,4,5-tetrahydrobenzo[b][1,6]naphthyridin-10(2H)-one (CAS 1325306-24-8)
- 4-((4-Chloro-3-(trifluoromethyl)phenoxy)methyl)benzoic acid (CAS 1355637-18-1)
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Recommended Standards
- Methyl 2-chloro-4-[3-(trifluoromethoxy)phenyl]benzoate (CAS 1820704-79-7)
- Methyl 4-chloro-2-hydroxy-3-(trifluoromethyl)-[1,1-biphenyl]-4-carboxylate (CAS 1951451-61-8)
- 4-Chloro-2-(4-(trifluoromethoxy)phenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (CAS 1956381-44-4)
- (E)-3-Chloro-N'-hydroxy-N-[(pyridin-3-yl)methyl]-5-(trifluoromethyl)pyridine-2-carboximidamide (CAS 320420-32-4)
- 5-Fluoroisoquinolin-1(2H)-one (CAS 410086-25-8)
- 2,5-Di(pyridin-3-yl)-1,3,4-oxadiazole (CAS 15420-57-2)
- 5-(4-formylphenoxymethyl)-3-methylfuran-2-carboxylic acid (CAS 1153306-99-0)
- 1-(Tetrahydrothiophen-3-yl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1707594-44-2)
- 6-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine hydrochloride (CAS 1210247-51-0)
- 8-Hydroxy-2H-benzo[b][1,4]thiazin-3(4H)-one (CAS 91375-76-7)
- (S)-2-((R)-tert-Butylsulfinyl)-1-methyl-2,6-diazaspiro[3.3]heptane (CAS 2847094-22-6)
- [2-(methylsulfanyl)pyridin-4-yl]methanamine (CAS 1160059-05-1)
- N-(4-fluorophenyl)-6-(methylsulfonyl)pyridazin-3-amine (CAS 400086-99-9)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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