(1s)-2,2-Difluoro-1-(2-fluorophenyl)ethan-1-ol CAS 1821768-76-6
| CAS No. | 1821768-76-6 |
| Molecular Formula | C8H7F3O |
| Molecular Weight | 176.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(1s)-2,2-Difluoro-1-(2-fluorophenyl)ethan-1-ol (CAS 1821768-76-6) is a high-purity analytical reference standard with the molecular formula C8H7F3O and a molecular weight of 176.14 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, (1s)-2,2-Difluoro-1-(2-fluorophenyl)ethan-1-ol is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 176.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F3O |
| Molecular Weight | 176.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related s Standards
- 2,2-Difluoro-2-(3-fluorophenyl)ethan-1-ol (CAS 1341215-25-5)
- 2,2-Difluoro-2-(2-fluorophenyl)ethanol (CAS 1380202-32-3)
- (S)-2,2-Difluoro-1-(3-fluorophenyl)ethan-1-ol (CAS 1821734-28-4)
- 2,2-Difluoro-1-(4-fluorophenyl)ethan-1-ol (CAS 2546-44-3)
- 2,2-Difluoro-2-(4-fluorophenyl)ethanol (CAS 762292-74-0)
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