Posaconazole Impurity 97 CAS 182210-71-5
| CAS No. | 182210-71-5 |
| Molecular Formula | 2*C12H13F2IO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Posaconazole Impurity 97 (CAS 182210-71-5) is a certified pharmaceutical impurity reference standard with the molecular formula C12H13F2IO2 and a molecular weight of 354.13 g/mol.
Posaconazole Impurity 97 (C12H13F2IO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C12H13F2IO2 |
| Molecular Weight | 354.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F/I-containing |
Related Posaconazole Standards
- Posaconazole Impurity 25 (CAS 1042398-26-4)
- Posaconazole Impurity 112 (CAS 110931-77-6)
- Posaconazole Impurity 111 (CAS 112559-81-6)
- Posaconazole-d4 (CAS 1133712-26-1)
- Posaconazole Impurity 84 (CAS 122151-32-0)
- Posaconazole Impurity 115 (CAS 122151-38-6)
- Posaconazole Impurity 67(R,S,R,R) (CAS 1229428-89-0)
- Posaconazole Impurity 22(R,S,S,R) (CAS 1229428-90-3)
Recommended Standards
- Ramelteon Impurity 14 (CAS 326793-94-6)
- Vitamin A impurity 5(Mixture of E/Z Isomers) (CAS CATO-C4X-25505-SS)
- Carfilzomib Impurity 96 (CAS CATO-C4X-102296)
- 3-(2-Oxo-2-phenylethyl)benzoic acid (CAS 898766-97-7)
- Leptolepisol B (CAS 71332-94-0)
- [3,3'-bithiophen]-5-ylmethanamine (CAS 177976-52-2)
- 2,6-difluoro-4-hydroxyphenylboronic acid (CAS 957065-87-1)
- tert-butyl (2S,4R)-4-azido-2-(difluoromethyl)pyrrolidine-1-carboxylate (CAS 1207852-95-6)
- N-(3-aminocyclobutyl)methanesulfonamide hydrochloride (CAS 1258640-74-2)
- Neuropeptide K, porcine (CAS 106441-70-7)
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