5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(methylsulfonyl)pyrimidin-4-amine CAS 1823183-00-1
| CAS No. | 1823183-00-1 |
| Molecular Formula | C11H8ClF3N4O2S |
| Molecular Weight | 352.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(methylsulfonyl)pyrimidin-4-amine (C11H8ClF3N4O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies 5-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-(methylsulfonyl)pyrimidin-4-amine (CAS 1823183-00-1), a certified reference material (molecular formula C11H8ClF3N4O2S, MW 352.72 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8ClF3N4O2S |
| Molecular Weight | 352.72 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)benzenesulfonamide (CAS 1427460-72-7)
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- 2-((2-Chloro-6-fluorobenzyl)thio)-3-methyl-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 339101-79-0)
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Recommended Standards
- 2,4,5-Trichloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 1313036-72-4)
- Dimethyl 1-(2-((4-chlorophenyl)amino)-2-oxoethyl)-1H-1,2,3-triazole-4,5-dicarboxylate (CAS 124193-36-8)
- Chloromonilinic Acid B (CAS 121927-79-5)
- Regorafenib Impurity 18 (CAS CATO-C4X-104718)
- 2,8-Dimethyl-5-(2-(6-methylpyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride hydrate (CAS 1186653-04-2)
- Methyl 3-oxotetrahydro-2H-thiopyran-2-carboxylate (CAS 38555-41-8)
- 2-Amino-5-methyl-5-phenyloxazol-4(5H)-one (CAS 51038-39-2)
- 2-(3,5-Dibromophenyl)-1-phenyl-1H-benzo[d]imidazole (CAS 953091-79-7)
- 3-(3-Methyl-4-nitrophenoxy)pyrrolidine 4134AF 946760-47-0 C11H14N2O3 (CAS 946760-47-0)
- 1-(4-Bromophenyl)-3-((4-phenoxyphenyl)amino)propan-1-one (CAS 477334-11-5)
- (+)-Biotinylbutylamine, 97% (CAS 151294-96-1)
- 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine-1-sulfonamide (CAS 1882065-27-1)
- [2-Chloro-5-(trifluoromethyl)phenyl](4-fluorophenyl)methanone (CAS 85721-08-0)
- 107444-51-9 0JS9125PIZ Glucagon-like peptide 1 (7-36) Glucagon-related peptide 1 (Rana catesbeiana), 3-L-glutamic acid-10-L-valine-16-glycine-17-L-glutamine-23-L-isoleucine-24-L-alanine-27-L-valine-30-L-argininamide-31-de-L-proline-32-de-L-lysine- Glp-I (7-36) Proglucagon (78-107) Human glucagon-like peptide-1-(7-36) amide Human GLP-1-(7-36)-amide Glucagon-like peptide-I(7-36) amide Rat GLP-I(7-36)amide Insulinotropin (human) MKC 253 UNII-0JS9125PIZ (CAS 107444-51-9)
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