2-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methylidene)-2,3-dihydro-1H-indene-1,3-dione CAS 366021-91-2
| CAS No. | 366021-91-2 |
| Molecular Formula | C16H8ClF3N2O2 |
| Molecular Weight | 352.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methylidene)-2,3-dihydro-1H-indene-1,3-dione.
2-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methylidene)-2,3-dihydro-1H-indene-1,3-dione (CAS 366021-91-2) is a high-purity analytical reference standard with the molecular formula C16H8ClF3N2O2 and a molecular weight of 352.70 g/mol.
The molecular framework of 2-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methylidene)-2,3-dihydro-1H-indene-1,3-dione (C16H8ClF3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H8ClF3N2O2 |
| Molecular Weight | 352.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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