4-Chloro-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidine CAS 1823188-18-6
| CAS No. | 1823188-18-6 |
| Molecular Formula | C10H3Cl2F4N3 |
| Molecular Weight | 312.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidine.
CATO supplies 4-Chloro-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidine (CAS 1823188-18-6), a certified reference material (molecular formula C10H3Cl2F4N3, MW 312.05 g/mol) for analytical method development and quality control.
Structurally, 4-Chloro-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidine (C10H3Cl2F4N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 312.05 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H3Cl2F4N3 |
| Molecular Weight | 312.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 2-Benzyloxy-4-(trifluoromethoxy)phenylboronic acid (CAS 1704064-19-6)
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- 6-Chloro-3-nitro-1H-pyrrolo[3,2-b]pyridine (CAS 1190311-54-6)
- 3-Phenoxypyridin-4-amine (CAS 132038-33-6)
- 2-(3-(Difluoromethoxy)-4-methoxyphenyl)ethanethioamide (CAS 1193389-41-1)
- Methyl N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(phenylsulfonyl)glycinate (CAS 713112-11-9)
- 2-(4-bromo-1H-1,3-benzodiazol-2-yl)ethan-1-amine (CAS 4507-68-0)
- 6-Acetylnicotinic acid (CAS 20857-23-2)
- (2S,4R)-Methyl 4-hydroxy-5-oxotetrahydrofuran-2-carboxylate (CAS 123356-13-8)
- N-benzyl-N-(1-methyl-2-thien-2-ylethyl)amine (CAS 791601-01-9)
- Semaglutide impurity 80 (CAS CATO-C4X-222680)
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