Ketamine EP Impurity B CAS 1823362-29-3
| CAS No. | 1823362-29-3 |
| Molecular Formula | C12H13ClO2 |
| Molecular Weight | 224.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ketamine EP Impurity B is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Ketamine EP Impurity B (CAS 1823362-29-3), a pharmacopoeial impurity reference standard (molecular formula C12H13ClO2, MW 224.68 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Ketamine EP Impurity B (C12H13ClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ketamine EP Impurity B under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H13ClO2 |
| Molecular Weight | 224.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
Related Ketamine Standards
Recommended Standards
- Esketamine EP Impurity C (CAS 90717-17-2)
- 5-Chloro-2-(1-piperazinyl)-benzaldehyde (CAS 1001328-96-6)
- 731772-89-7 Ethyl 4-(2-chloroprop-2-en-1-yl)benzoate DTXSID40641158 (CAS 731772-89-7)
- (3-Chlorophenyl)(piperazin-1-yl)methanone (CAS 100939-90-0)
- Lansoprazole Impurity 10 (CAS 1083100-27-9)
- Atorvastatin Impurity 148 Calcium Salt (CAS 887470-43-1 (free acid))
- Granisetron EP Impurity C Hydrochloride (CAS 141136-01-8)
- S-Palmitoyl-L-cysteine (CAS 114507-35-6)
- 1-(3-Methoxyquinoxalin-2-yl)piperidin-4-ol (CAS 1065484-15-2)
- (S)-1-Boc-3-cyanopiperazine (CAS 1217650-60-6)
- 4-Bromo-3-methyl-2,3-dihydro-1h-inden-1-one (CAS 102539-53-7)
- 1-[3-(Morpholin-4-yl)-5-(trifluoromethyl)pyridin-2-yl]ethan-1-one (CAS 866145-10-0)
- D-Altrose (CAS 1990-29-0)
- Insulin Degludec Impurity 16 (CAS CATO-C4X-215716)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com