Esketamine EP Impurity C CAS 90717-17-2
| CAS No. | 90717-17-2 |
| Molecular Formula | C12H13ClO2 |
| Molecular Weight | 224.68 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 224.68 g/mol gives Esketamine EP Impurity C distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Esketamine EP Impurity C (CAS 90717-17-2, C12H13ClO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Esketamine EP Impurity C (C12H13ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 224.68 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13ClO2 |
| Molecular Weight | 224.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1982 |
| Halogen Content | Cl-containing |
Related Esketamine Standards
- Esketamine (CAS 33643-46-8)
- Esketamine EP Impurity D (CAS 33643-49-1)
- Esketamine Hydrochloride (CAS 33643-47-9)
- 【禁售不询】Esketamine Impurity N1 (CAS 6740-88-1)
- Esketamine Impurity 5 (CAS 86144-35-6)
- Esketamine Impurity 8 (CAS CATO-C4X-19048)
- Esketamine Impurity 9 (CAS CATO-C4X-19049)
- Esketamine Impurity 7 (CAS CATO-C4X-19047)
Recommended Standards
- 731772-89-7 Ethyl 4-(2-chloroprop-2-en-1-yl)benzoate DTXSID40641158 (CAS 731772-89-7)
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- Retigabine impurity 17 (CAS CATO-C4X-13157)
- Sunitinib Impurity 33 (CAS 1186651-51-3)
- Hydantoin Impurity 5 (CAS 1433954-32-5)
- 1-azido-4-bromo-2-chlorobenzene (CAS 1152943-47-9)
- 2,2,2-Trifluoro-1-(2-fluoro-5-nitrophenyl)ethan-1-ol (CAS 2229409-70-3)
- 1-cyclopropyl-1,4-diazepan-5-one (CAS 30858-70-9)
- 2-Oxo-1-phenyl-2,4,5,6-tetrahydro-1H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid (CAS 1818871-20-3)
- 2-((1,4-Diazepan-1-yl)sulfonyl)benzo[d]thiazole (CAS 1411763-06-8)
- 5-(2-Methylphenyl)-1h-pyrazole-4-carboxylic acid (CAS 1007541-87-8)
- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
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