Voriconazole EP Impurity B(Voriconazole Related Compound D) CAS 182369-73-9
| CAS No. | 182369-73-9 |
| Molecular Formula | 2*C16H15F2N5O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Voriconazole EP Impurity B(Voriconazole Related Compound D).
As a process- or degradation-related impurity, Voriconazole EP Impurity B(Voriconazole Related Compound D) (CAS 182369-73-9, C16H15F2N5O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H15F2N5O, Voriconazole EP Impurity B(Voriconazole Related Compound D) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 331.33 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 2*C16H15F2N5O |
| Molecular Weight | 331.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Voriconazole Standards
- Voriconazole Impurity 70 (CAS 115617-41-9)
- Voriconazole Impurity 31 (CAS 1157981-64-0)
- Voriconazole Impurity 60 (CAS 116622-90-3)
- Voriconazole Impurity 59 (CAS 1185186-22-4)
- Voriconazole-d3 (CAS 1217661-14-7)
- Voriconazole-d3 N-OxideDISCONTINUED. Please see V760013 (CAS 1217851-84-7)
- Voriconazole Impurity 44 (CAS 1289559-66-5)
- Voriconazole Impurity 65 (CAS 1289559-76-7)
Recommended Standards
- Venetoclax Impurity 62 (CAS CATO-C4X-249562)
- Vilanterol Impurity 55 (CAS CATO-C4X-193555)
- Desmopressin Impurity 12 (CAS CATO-C4X-221512)
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- 2-Methyl-1-((tetrahydro-2h-thiopyran-4-yl)amino)propan-2-ol (CAS 1477963-27-1)
- 2-Chloro-N-(4-methylbenzyl)quinazolin-4-amine (CAS 938524-71-1)
- 2-(4-Fluorobenzoyl)pyridine (CAS 169955-75-3)
- 2-(methylthio)-6-phenylpyrimidin-4(3H)-one (CAS 56035-29-1)
- 1-((1H-Benzo[d][1,2,3]triazol-1-yl)methyl)indolin-2-one (CAS 147227-57-4)
- (Asp28)-Exenatide trifluoroacetate salt (CAS 1678417-24-7)
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