2-Chloro-4-fluoronicotinamide CAS 1823944-18-8
| CAS No. | 1823944-18-8 |
| Molecular Formula | C6H4ClFN2O |
| Molecular Weight | 174.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Chloro-4-fluoronicotinamide (CAS 1823944-18-8), a certified reference material (molecular formula C6H4ClFN2O, MW 174.56 g/mol) for analytical method development and quality control.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 2-Chloro-4-fluoronicotinamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 174.56 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-4-fluoronicotinamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H4ClFN2O |
| Molecular Weight | 174.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-3-fluorobenzoic Acid (CAS 102940-86-3)
- 2-Chloro-5-fluoro-4-hydroxybenzaldehyde (CAS 1036383-27-3)
- 2-Chloro-6-fluoro-3-hydroxybenzaldehyde (CAS 1083103-41-6)
- 3-Chloro-6-fluoro-2-hydroxybenzaldehyde (CAS 1185112-08-6)
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- 2-Chloro-3-fluoro-6-hydroxybenzaldehyde (CAS 1263378-00-2)
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- 2-chloro-3-fluoropyridine-4-carboxamide (CAS 1378654-14-8)
Recommended Standards
- 4-Chloro-5-fluoronicotinamide (CAS 1706432-64-5)
- 6-Chloro-3-fluoropicolinamide (CAS 1851115-33-7)
- 6-Chloro-2-fluoro-3-hydroxybenzaldehyde (CAS 1704729-56-5)
- 1-(2-Chloro-5-fluoropyrimidin-4-yl)ethan-1-one (CAS 736991-76-7)
- 4-Chloro-1-methoxy-2-(1,1,1-trifluoro-2-methylpropan-2-yl)benzene (CAS 1402004-24-3)
- 1-(4-Chlorobenzyl)pyrrolidin-3-ol (CAS 415946-61-1)
- 2-(3-ethoxy-4-methoxyphenyl)ethanamine (CAS 86456-97-5)
- Ethyl 1-(4-chlorophenyl)-3-methyl-4-((3-(trifluoromethyl)benzyl)amino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 866132-88-9)
- 3-Amino-6-isopropylpicolinic acid (CAS 1393561-33-5)
- 1,2,3,4-tetrahydronaphthalene-2,6-diamine dihydrochloride (CAS 861333-04-2)
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- (S)-1-Cyclopropyl-N-(4-fluorobenzyl)ethan-1-amine (CAS 1889287-64-2)
- 2-Acetoxy-3,5-methoxybenzophenone (CAS 890098-98-3)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com