4-Amino-3-fluorophenol hydrochloride CAS 18266-53-0
| CAS No. | 18266-53-0 |
| Molecular Formula | C6H6FNO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 163.58 g/mol gives 4-Amino-3-fluorophenol hydrochloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-Amino-3-fluorophenol hydrochloride (CAS 18266-53-0), molecular formula C6H6FNOHCl and molecular weight 163.58 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Amino-3-fluorophenol hydrochloride (C6H6FNOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6FNO HCl |
| Molecular Weight | 163.58 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Amino Standards
- 3-Amino-1-methyl-4-phenoxyindazole (CAS 1000018-07-4)
- 3-Amino-2,6-dibromo-5-ethoxypyridine (CAS 1000018-10-9)
- Methyl 2-amino-5-bromo-4-isopropylbenzoate (CAS 1000018-13-2)
- Methyl 2-amino-3-(pyridin-2-yl)propanoate (CAS 100002-84-4)
- 100005-23-0 2-Amino-4-(4-methoxyphenyl)-5-methylthiophene-3-carbonitrile 7050AC C13H12N2OS (CAS 100005-23-0)
- Methyl 1-amino-4-cyano-1H-pyrrole-2-carboxylate (CAS 1000313-12-1)
- 6-Amino-7-hydroxy-2,3-dihydro-1H-inden-1-one hydrobromide (CAS 1000333-87-8)
- 6-Amino-7-iodo-2,3-dihydro-1H-inden-1-one (CAS 1000333-93-6)
Recommended Standards
- 2-fluoro-2-phenylcyclopropan-1-amine hydrochloride (CAS 1909336-40-8)
- 1-(Pyridin-2-yl)ethyl piperidine-4-carboxylate (CAS 154348-19-3)
- 3-(3-Methylphenyl)-1,2-oxazol-5-ol (CAS 1354938-89-8)
- 3-({[(2,6-dichlorophenyl)methyl]sulfanyl}methyl)-5-{[(4-nitrophenyl)methyl]sulfanyl}-4-phenyl-4H-1,2,4-triazole (CAS 344271-60-9)
- 69878-18-8 Hexanoic acid, 2,6-diisocyanato-, 2-isocyanatoethyl ester 2-Isocyanatoethyl 2,6-diisocyanatohexanoate 2,6-Diisocyanatohexanoic acid, 2-isocyanatoethyl ester EINECS 274-179-0 (CAS 69878-18-8)
- (Z)-6-chloro-N'-hydroxy-1H-indole-3-carboximidamide (CAS 889942-64-7)
- Tuberculostearic Acid Ethyl Ester (CAS 158648-65-8)
- 6-(4-Chlorophenyl)-5,6-dihydro-8H-imidazo[5,1-c][1,4]oxazine-1-carboxylic acid (CAS 1416338-58-3)
- Avanafil Impurity 44 (CAS CATO-C4X-111844)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com