5-Acetyl-2-(4-fluorophenyl)-5-methyloxazol-4(5H)-one CAS 18354-42-2
| CAS No. | 18354-42-2 |
| Molecular Formula | C12H10FNO3 |
| Molecular Weight | 235.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Acetyl-2-(4-fluorophenyl)-5-methyloxazol-4(5H)-one (C12H10FNO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 5-Acetyl-2-(4-fluorophenyl)-5-methyloxazol-4(5H)-one (CAS 18354-42-2), a certified reference material (molecular formula C12H10FNO3, MW 235.21 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10FNO3 |
| Molecular Weight | 235.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Acetyl Standards
- 5-Ethyl-1-(4-fluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1017470-82-4)
- 5-Ethyl-1-(3-fluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1094311-25-7)
- Ethyl 5-(2-Fluorophenyl)isoxazole-3-carboxylate (CAS 1126636-56-3)
- Methyl 1-(2-fluorophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate (CAS 1147207-80-4)
- 5-Ethyl-1-(2-fluorophenyl)-1h-1,2,4-triazole-3-carboxylic acid (CAS 1154370-83-8)
- [2-(4-Fluorophenyl)-4-methyl-1,3-oxazol-5-yl]acetic acid (CAS 1172370-81-8)
- 1-[2-(2-fluorophenyl)-2-oxoethyl]pyrrolidine-2,5-dione (CAS 1258652-22-0)
- Ethyl 5-(2-fluorophenyl)oxazole-4-carboxylate (CAS 127919-29-3)
Recommended Standards
- 5-Fluoro-N-((5-methyloxazol-4-yl)methyl)nicotinamide (CAS 1797961-79-5)
- Ethyl 5-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 185011-40-9)
- Methyl 7-fluoro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 1785760-67-9)
- 6-Amino-1-(4-fluorophenyl)-3-methylpyrimidine-2,4(1H,3H)-dione (CAS 19369-30-3)
- 6-Methylisoxazolo[5,4-b]pyridin-3(2H)-one (CAS 178748-11-3)
- 2-(4-Formyl-3-phenyl-1h-pyrazol-1-yl)acetic acid (CAS 353514-39-3)
- 4-Fluoro-3-[(4-fluorophenyl)(hydroxy)methyl]phenylboronic acid (CAS 2377587-42-1)
- Methanone, [3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl][4-(2-ethoxyphenyl)-1-piperazinyl]- (CAS 1016491-92-1)
- Dimethylphenylsilanol (CAS 5272-18-4)
- 3-epi-Ursolic Acid (CAS 989-30-0)
- Ethyl 2-Cyano-3-phenylpropanoate (CAS 6731-58-4)
- 4-(tert-Butyl)-3-cyclopropoxy-2-(methylthio)pyridine (CAS 1243353-95-8)
- 1-(4-Nitrophenyl)-2-phenylethane-1,2-dione (CAS 22711-24-6)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com