2,3-Difluoroacetophenone CAS 18355-80-1
| CAS No. | 18355-80-1 |
| Molecular Formula | C8H6F2O |
| Molecular Weight | 156.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 156.13 g/mol gives 2,3-Difluoroacetophenone distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2,3-Difluoroacetophenone (CAS 18355-80-1), molecular formula C8H6F2O and molecular weight 156.13 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C8H6F2O, 2,3-Difluoroacetophenone contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 156.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2,3-Difluoroacetophenone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O |
| Molecular Weight | 156.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
Related Difluoroacetophenone Standards
- 2’,6’-Difluoroacetophenone (CAS 13670-99-0)
- 2,5-Difluoroacetophenone (CAS 1979-36-8)
- , -Difluoroacetophenone 2,2-Difluoro-1-phenylethanone 2,2-Difluoroacetophenone 395-01-7 Difluoromethyl phenyl ketone a,a-difluoroacetophenone alpha,alpha-difluoroacetophenone (CAS 395-01-7)
- 3′,5′-difluoroacetophenone (CAS 123577-99-1)
Recommended Standards
- (E)-[(2,5-Difluorophenyl)methylidene]hydrazine (CAS 1820748-99-9)
- 1-(Difluoromethyl)-4-ethynyl-5-methyl-1H-pyrazole (CAS 1855889-94-9)
- 5,7-Difluoro-2,3-dihydrobenzofuran (CAS 175203-20-0)
- 1-(2,2-Difluoroethyl)-4-ethynyl-1H-pyrazole (CAS 1855890-49-1)
- (2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid (CAS 1297550-14-1)
- 5,6-Difluoro-3-nitro-1H-indole (CAS 2138239-73-1)
- (S)-Ethyl 1-methylpyrrolidine-2-carboxylate (CAS 936-14-1)
- Ethanol, polymer with tantalum chloride (TaCl5) (CAS 135929-42-9)
- 1-Cyclobutyl-3-(2,2-dimethylthietan-3-yl)urea (CAS 1852730-88-1)
- 3-Chloro-2-methyl-5H-cyclopenta[b]pyridin-7(6H)-one (CAS 1447606-10-1)
- IACS-10759 (CAS 1570496-34-2)
- Cortisol 21-sulfate potassium salt (CAS 152957-32-9)
- 4-Methyl-2-(methylthio)-6-oxo-1,6-dihydropyridine-3-carboxylic acid (CAS 869634-09-3)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
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