Glycerol Impurity 35 CAS 18371-75-0
| CAS No. | 18371-75-0 |
| Molecular Formula | C7H15ClO3 |
| Molecular Weight | 182.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Glycerol Impurity 35.
As a process- or degradation-related impurity, Glycerol Impurity 35 (CAS 18371-75-0, C7H15ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Glycerol Impurity 35 (C7H15ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Glycerol Impurity 35 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H15ClO3 |
| Molecular Weight | 182.65 g/mol |
| Purity | ＞98% |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Glycerol Standards
- Glycerol Impurity 36 (CAS 14180-03-1)
- Glycerol α,α-Diallyl Ether (CAS 17018-07-4)
- Glycerol 1-Phosphate (CAS 57-03-4)
- Glycerol monomercaptoacetate (CAS 30618-84-9)
- Glycerol 1-Monobutyrate (CAS 557-25-5)
- Glycerol Impurity 41 (CAS 42320-97-8)
- Glycerol Impurity 42 (CAS 25664-08-8)
- Glycerol Impurity 10 (Disulfide Oxidation Product) (CAS 4807-52-7)
Recommended Standards
- Loxoprofen Impurity 17 (CAS 69673-92-3)
- Dapoxetine Impurity 31 (CAS 22422-21-5)
- (4-Chlorobutyl)(4-Fluorobutyl) Ether (CAS 593-22-6)
- 63667-85-6 1-(2-Chloroprop-2-en-1-yl)-2-methoxybenzene DTXSID40641178 (CAS 63667-85-6)
- Ambroxol Impurity 33 HCl (CAS 101900-44-1)
- Daprodustat Impurity 23 (CAS CATO-C4X-240723)
- Ciprofloxacin Impurity 20 (CAS CATO-C4X-136220)
- Methyl 3,4-dibromo-2-fluorophenylacetate (CAS 1806307-58-3)
- 1-Benzyl-5-(p-tolyl)-1H-imidazole-2-thiol (CAS 1105188-70-2)
- (S)-2-((tert-Butoxycarbonyl)amino)hex-4-ynoic acid (CAS 98254-05-8)
- 2-Methyl-[1,1'-biphenyl]-4-ol (CAS 88187-82-0)
- 1-(Benzyloxy)-3,3-dimethylbutan-2-one (CAS 80489-22-1)
- Dithiopyr (CAS 97886-45-8)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
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