Lercanidipine Impurity 18 HCl CAS 184866-29-3
| CAS No. | 184866-29-3 |
| Molecular Formula | C36H41N3O6 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lercanidipine Impurity 18 HCl is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Lercanidipine Impurity 18 HCl (CAS 184866-29-3, C36H41N3O6HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Lercanidipine Impurity 18 HCl (C36H41N3O6HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lercanidipine Impurity 18 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C36H41N3O6 HCl |
| Molecular Weight | 648.20 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Lercanidipine Standards
- Lercanidipine Impurity 36 (CAS 100427-26-7)
- Lercanidipine Impurity 60 (CAS 100427-51-8)
- Lercanidipine Impurity 7 (CAS 100442-33-9)
- Lercanidipine Impurity 38 (CAS 10317-10-9)
- Lercanidipine Impurity 19 (CAS 111304-32-6)
- Lercanidipine Impurity 5 (CAS 1119226-97-9)
- Lercanidipine-d3 Hydrochloride (CAS 1189954-18-4)
- (+/-) Lercanidipine D3 (CAS 1190043-34-5)
Recommended Standards
- Atrasentan Impurity 91 (CAS 1059043-44-5)
- Rosuvastatin Impurity 268 (CAS CATO-C4X-1169268)
- Silodosin Impurity 31 (CAS CATO-C4X-175431)
- 5-(Cyclopropylmethoxy)picolinaldehyde (CAS 1502637-39-9)
- n-(1-(3-Fluoro-4-methoxyphenyl)ethyl)cyclopropanecarboxamide (CAS 1061126-57-5)
- tert-Butyl 3-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)pyrrolidine-1-carboxylate (CAS 2376764-71-3)
- 6-Amino-1-(2-methoxyethyl)-5-(piperidin-1-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione (CAS 790232-14-3)
- 1-Naphthalenamine, 8-(diphenylphosphino)-1,2,3,4-tetrahydro-, (1S)-, tetrafluoroborate(1-) (1:1) (CAS 1222630-46-7)
- Palonosetron Impurity 12 DiHCl (CAS 177793-80-5(free base))
- Semaglutide impurity 98 (CAS CATO-C4X-222698)
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