Acotiamide Impurity 28 CAS 185104-11-4
| CAS No. | 185104-11-4 |
| Molecular Formula | C21H30N4O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Acotiamide Impurity 28 (CAS 185104-11-4) is a certified pharmaceutical impurity reference standard with the molecular formula C21H30N4O5SHCl and a molecular weight of 487.01 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Acotiamide Impurity 28 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 487.01 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Acotiamide Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H30N4O5S HCl |
| Molecular Weight | 487.01 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Acotiamide Standards
- Acotiamide Impurity M (CAS 118452-02-1)
- Acotiamide Impurity 21 (CAS 118452-04-3)
- Acotiamide Impurity 25 (CAS 163936-30-9)
- Acotiamide Impurity 4 (CAS 1809272-85-2)
- Acotiamide Impurity 3 (CAS 1824734-16-8)
- Acotiamide Impurity 23 (CAS 185103-81-5)
- Acotiamide Impurity 7 (CAS 185105-13-9)
- Acotiamide Impurity 8 Maleate (CAS 185105-17-3)
Recommended Standards
- Tirofiban Impurity 60 (CAS CATO-C4X-125460)
- Cefaclor EP Impurity E (CAS 188915-50-6)
- Chlorhexidine Impurity 6 (CAS 62247-48-7)
- 3-Methyl-N-(piperidin-4-yl)benzamide (CAS 836685-70-2)
- N-Formyl-DL-alanine (CAS 5893-10-7)
- Tetrabutylphosphonium O,O-diethyl Phosphorodithioate (CAS 96131-57-6)
- Diethyl (2-oxobutyl)phosphonate (CAS 1067-73-8)
- 3-Bromo-5-ethylthiophene-2-carbaldehyde (CAS 1368144-65-3)
- N-(4-(3,4-Dihydroisoquinolin-2(1H)-yl)but-2-yn-1-yl)-5-phenylisoxazole-3-carboxamide (CAS 1351660-23-5)
- D-Tyr10-Tirzepatide (CAS CATO-CPTD788922)
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