Chlorhexidine Impurity 6 CAS 62247-48-7
| CAS No. | 62247-48-7 |
| Molecular Formula | C22H28Cl2N8O2 |
| Molecular Weight | 507.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 507.42 g/mol gives Chlorhexidine Impurity 6 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Chlorhexidine Impurity 6 (CAS 62247-48-7, C22H28Cl2N8O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Chlorhexidine Impurity 6 (C22H28Cl2N8O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Chlorhexidine Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H28Cl2N8O2 |
| Molecular Weight | 507.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1974 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 8 |
Related Chlorhexidine Standards
- Chlorhexidine EP Impurity O (CAS 2508008-02-2)
- Chlorhexidine (CAS 55-56-1)
- Chlorhexidine-d8 Dihydrochloride (CAS 1246816-96-5)
- Chlorhexidine EP Impurity M (CAS 152504-12-6)
- Chlorhexidine Impurity 24 (CAS CATO-C4X-225624)
- Chlorhexidine Impurity 36 (CAS CATO-C4X-225636)
- Chlorhexidine Impurity 18 (CAS CATO-C4X-225618)
- Chlorhexidine Diacetate EP Impurity B (CAS 1308292-89-8)
Recommended Standards
- 1,1,1-Trifluoro-N-[(11bS)-8,9,10,11,12,13,14,15-octahydro-2,6-dimethyl-4-oxidodinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl]methanesulfonamide (CAS 2757287-62-8)
- 2-((N-(5-(Benzyloxy)-2,4-dichlorophenyl)-4-methylphenyl)sulfonamido)-N,N-dimethylacetamide (CAS 338967-32-1)
- Melphalan Impurity 36 (CAS CATO-C4X-198836)
- Sitagliptin Impurity 22 (CAS 486460-23-5)
- Bortezomib Impurity 21 (CAS 18680-27-8)
- Rivaroxaban Impurity 206 (CAS CATO-C4X-1090206)
- Formoterol EP Impurity G (CAS 23239-32-9)
- 4-Carbamoyl-1H-imidazol-5-yl benzo[d][1,3]dioxole-5-carboxylate (CAS 66148-63-8)
- N-(3-Benzoyl-5-chlorothiophen-2-yl)-2-chloroacetamide (CAS 30199-09-8)
- Dobutamine Impurity 35 (CAS CATO-C4X-129835)
- Dipyridamole Tartaric Acid Mono Ester (CAS 68006-07-5)
- rel-tert-Butyl (1R,4R,5S)-5-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate (CAS 198835-03-9)
- 2-Methoxy-1-naphthimidamide (CAS 885270-13-3)
- Semaglutide impurity 202 (CAS CATO-C4X-2226202)
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