8-(Chloromethyl)-1-naphthonitrile CAS 18512-45-3
| CAS No. | 18512-45-3 |
| Molecular Formula | C12H8ClN |
| Molecular Weight | 201.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
8-(Chloromethyl)-1-naphthonitrile (CAS 18512-45-3) is a high-purity analytical reference standard with the molecular formula C12H8ClN and a molecular weight of 201.65 g/mol.
The molecular framework of 8-(Chloromethyl)-1-naphthonitrile (C12H8ClN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 8-(Chloromethyl)-1-naphthonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClN |
| Molecular Weight | 201.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
- 2-(Chloromethyl)4-fluorobenzothiazole (CAS 110704-21-7)
- 2-(Chloromethyl)-5-fluorobenzo[d]thiazole (CAS 110704-60-4)
- 4-(Chloromethyl)-1-naphthonitrile (CAS 112929-87-0)
- 4-(Chloromethyl)-2-naphthonitrile (CAS 112929-91-6)
- 2-Chloromethyl-6-fluorobenzo[d]thiazole, 97% (CAS 124050-14-2)
- 1-(chloromethyl)naphthalene-2-carbonitrile (CAS 1261626-83-8)
- 3-(Chloromethyl)-5-(piperidin-1-yl)-1,2,4-oxadiazole (CAS 1393567-57-1)
- 2-(Chloromethyl)-5-(tetrahydro-2H-pyran-4-yl)oxazole (CAS 1491338-21-6)
Recommended Standards
- 3-Fluoropiperidine-1-sulfonyl chloride (CAS 1845693-87-9)
- 2-Butoxy-3-chloropyridin-4-ol (CAS 1881290-74-9)
- (5-Chloro-2-isopropoxy-pyridin-3-yl)-methanol (CAS 1826110-07-9)
- 3-Chloro-2-(2-methylpropoxy)pyridin-4-ol (CAS 1881293-61-3)
- 4-[(7-Chloroquinolin-4-ylAmino]-2-(Diethylaminomethyl)-3,6-Difluorophenol (CAS 155020-40-9)
- tert-Butyl 3-(3-chloropropyl)piperidine-1-carboxylate (CAS 1420848-37-8)
- (5-Methyl-2-(1-methylcyclohexyl)oxazol-4-yl)methanol (CAS 89743-88-4)
- 1-((2-Ethylhexyl)oxy)-4-methoxybenzene (CAS 146370-51-6)
- (4-(2-Methylthiazol-4-yl)phenyl)methanol (CAS 857283-96-6)
- 3-(tert-Butyl)-3,4-dihydro-2H-1,4-benzoxazine (CAS 32278-16-3)
- n-(2-(Dimethylamino)-2-(furan-2-yl)ethyl)cyclopropanecarboxamide (CAS 1209648-28-1)
- 1-(methylamino)cyclobutane-1-carboxylic acid hydrochloride (CAS 1909336-52-2)
- 2-Methyl-5-(trifluoromethyl)benzaldehyde (CAS 886498-85-7)
- Allo-D-Ile12-Tirzepatide (CAS CATO-CPTD788963)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com