N-(2,5-Difluorobenzyl)-1-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine hydrochloride CAS 1856049-84-7
| CAS No. | 1856049-84-7 |
| Molecular Formula | C13H12F5N3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
N-(2,5-Difluorobenzyl)-1-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine hydrochloride (CAS 1856049-84-7), molecular formula C13H12F5N3HCl and molecular weight 341.71 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(2,5-Difluorobenzyl)-1-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine hydrochloride (C13H12F5N3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C13H12F5N3 HCl |
| Molecular Weight | 341.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- (R)-1-(3,4-Difluorobenzyl)-2-oxo-N-(2-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)-1-phenylethyl)-1,2-dihydropyridine-3-carboxamide (CAS 1001409-50-2)
- Ethyl 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylate (CAS 1001412-63-0)
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic Acid (CAS 1001413-01-9)
- 1-(3,4-Difluorobenzyl)-2-oxo-N-(thiophen-2-ylmethyl)-1,2-dihydropyridine-3-carboxamide (CAS 1001413-87-1)
- Methyl 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylate (CAS 1001414-50-1)
- n-(3,5-Difluorobenzyl)-1-(1-methyl-1h-pyrazol-4-yl)methanamine (CAS 1006436-32-3)
- N-(3,5-difluorobenzyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)methanamine (CAS 1006436-76-5)
- n-(2,5-Difluorobenzyl)-1-(1,3-dimethyl-1h-pyrazol-4-yl)methanamine (CAS 1006449-75-7)
Recommended Standards
- Methyl 4-amino-1-ethyl-1H-indole-6-carboxylate (CAS 734532-90-2)
- 6-Chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine (CAS 291744-01-9)
- 5-Fluoro-2-(3-isopropylphenoxy)aniline (CAS 946716-97-8)
- 3-(Piperidin-1-ylsulfonyl)benzoic acid (CAS 7311-93-5)
- Methyl 5-(5-methyl-1H-pyrazol-3-yl)furan-2-carboxylate (CAS 1224742-89-5)
- (1S,3r,5R)-spiro[bicyclo[3.3.1]nonane-3,2’-oxirane]-7-one (CAS 53110-08-0)
- tert-Butyl(2-(methylthio)ethyl)carbamate (CAS 174360-08-8)
- Tunodafil Impurity 9 (CAS CATO-C4X-31109)
- 5-Bromo-4-(chloromethyl)-2-fluoropyridine (CAS 1227562-25-5)
- Des-Ile12-Aib13-Tirzepatide (CAS CATO-CPTD788960)
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