N-Fmoc-5-amino-2-chlorobenzoic acid CAS 186320-16-1
| CAS No. | 186320-16-1 |
| Molecular Formula | C22H16ClNO4 |
| Molecular Weight | 393.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-Fmoc-5-amino-2-chlorobenzoic acid.
CATO supplies N-Fmoc-5-amino-2-chlorobenzoic acid (CAS 186320-16-1), a certified reference material (molecular formula C22H16ClNO4, MW 393.82 g/mol) for analytical method development and quality control.
Structurally, N-Fmoc-5-amino-2-chlorobenzoic acid (C22H16ClNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 393.82 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H16ClNO4 |
| Molecular Weight | 393.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- N-Fmoc-4-amino-2-chlorobenzoic acid (CAS 186320-13-8)
- 2-(Fmoc-amino)-4-chlorobenzoic acid (CAS 332121-92-3)
- 2-(Fmoc-amino)-5-chlorobenzoic Acid (CAS 332121-90-1)
- Fmoc-β-(2-thienyl)-D-Ala-OH (CAS 201532-42-5)
- N-Fmoc-(3S)-3-amino-3-cyclohexylpropanoic acid (CAS 1260614-86-5)
- N-Fmoc-N-(cyclohexylmethyl)-glycine (CAS 1374785-49-5)
- Fmoc-n-methyl-tranexamic acid (CAS 173690-50-1)
- Fmoc-L-2-methylamino-7-octenoic acid (CAS 1808268-11-2)
Recommended Standards
- 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-chlorobenzoic acid (CAS 914348-17-7)
- 4-Chloro-3-({[(9h-fluoren-9-yl)methoxy]carbonyl}amino)benzoic acid (CAS 186320-11-6)
- 2-(3-Chlorophenyl)-1-((4-methylbenzyl)oxy)-6-nitro-1H-benzo[d]imidazole (CAS 303149-38-4)
- 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-chlorobenzoic acid (CAS 1537677-81-8)
- 4-Methoxy-3-methylbenzene-1,2-diol (CAS 77357-51-8)
- 5-Methyl-4-o-tolylthiazol-2-ylamine (CAS 16942-68-0)
- 4,4,5,5,5-Pentafluoropentyl propyl carbonate (CAS 1980086-71-2)
- (1R,5S)-3,8-diazabicyclo[3.2.1]octan-2-one (CAS 143393-97-9)
- 3-Bromo-4,5-dichloropyridine (CAS 1001056-83-2)
- 2-((4-Bromo-3,5-dimethylphenoxy)methyl)-1,3-dioxolane (CAS 1443354-66-2)
- 3-(2-Methylbutyl)piperidine (CAS 1219977-34-0)
- Atracurium Impurity 74 (CAS CATO-C4X-185074)
- 2-Hydrazinyl-5-(pyrrolidine-1-sulfonyl)pyridine (CAS 627843-11-2)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
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