Brinzolamide Impurity 28 CAS 186377-56-0
| CAS No. | 186377-56-0 |
| Molecular Formula | C11H19N3O5S3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 405.93 g/mol gives Brinzolamide Impurity 28 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Brinzolamide Impurity 28 (CAS 186377-56-0, C11H19N3O5S3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Brinzolamide Impurity 28 (C11H19N3O5S3HCl) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 405.93 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Brinzolamide Impurity 28 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H19N3O5S3 HCl |
| Molecular Weight | 405.93 g/mol |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 3 |
Related Brinzolamide Standards
- Brinzolamide D5 (CAS 1217651-02-9)
- Brinzolamide Impurity 13 (CAS 138890-50-3)
- Brinzolamide Impurity 23 (CAS 138890-58-1)
- Brinzolamide (CAS 138890-62-7)
- Brinzolamide Hydrochloride (CAS 150937-43-2)
- Brinzolamide Impurity 19 (CAS 154127-19-2)
- Brinzolamide Impurity 17 (CAS 154127-41-0)
- Brinzolamide Impurity 14 (CAS 154127-42-1)
Recommended Standards
- Anamorelin Impurity 10 (CAS CATO-C4X-286910)
- Dolasetron Impurity 2 (CAS 127951-99-9)
- Minocycline Impurity 14 (CAS CATO-C4X-169914)
- 2-(4-Bromo-1h-pyrazol-3-yl)-1,3-thiazole (CAS 166196-37-8)
- n-(2-phenylpropyl)cyclohexanamine (CAS 57203-53-9)
- (E)-N,N-Dimethyl-4-(2-(pyrimidin-4-yl)vinyl)aniline (CAS 917885-26-8)
- 2,5-Dichloro-n-(3-hydroxy-2-methylpropyl)thiophene-3-sulfonamide (CAS 1797163-16-6)
- 3,5-Difluoro-2-hydroxyphenacyl chloride (CAS 1706463-02-6)
- 1-(2-Butyloxazolidin-3-yl)ethanone (CAS 138531-20-1)
- Tirzepatide Impurity 19 X TFA Salt (CAS CATO-C4X-324019)
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