Pomalidomide Impurity 58 CAS 18658-36-1
| CAS No. | 18658-36-1 |
| Molecular Formula | C13H12N2O6 |
| Molecular Weight | 292.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Pomalidomide Impurity 58 (CAS 18658-36-1, C13H12N2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Pomalidomide Impurity 58 (C13H12N2O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Pomalidomide Impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12N2O6 |
| Molecular Weight | 292.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 2 |
Related Pomalidomide Standards
- Pomalidomide Impurity 54 (CAS CATO-C4X-135454)
- Pomalidomide Impurity 1 (CAS 1001852-14-7)
- Pomalidomide Impurity 2 (CAS 1001852-15-8)
- Pomalidomide Impurity 3 (CAS 2635-64-5)
- Pomalidomide Impurity 4 (CAS 918314-45-1)
- Pomalidomide M17 (CAS 1547162-41-3)
- Pomalidomide M16 (CAS 1547162-46-8)
- Pomalidomide M19 (CAS 460741-57-5)
Recommended Standards
- Flumazenil Impurity 14 (CAS 1291916-17-0)
- Minodronic Acid Impurity 17 (CAS CATO-C4X-124117)
- Entacapone Impurity 12 (CAS CATO-C4X-162912)
- 2-Methoxy-6,9-dichloroacridine 3,9-Dichloro-7-methoxyacridine 6,9-Dichloro-2-methoxyacridine 86-38-4 Acridine,9-dichloro-2-methoxy- Halocrin Halocrine NSC-2951 NSC2951 (CAS 86-38-4)
- Brinzolamide Impurity 13 (CAS 80-39-7)
- Omeprazole Impurity 19 (CAS 119-81-3)
- Prilocaine impurity 51 (CAS CATO-C4X-193451)
- 2-(Isopropylamino)-2-methyl-4-(1h-1,2,4-triazol-1-yl)butanamide (CAS 1250776-13-6)
- Methyl (2S,4S)-4-[(2-chloroacetyl)oxy]-2-pyrrolidinecarboxylate hydrochloride (CAS 1354488-12-2)
- 2-Ethylpentanal (CAS 22092-54-2)
- Dicyclohexyldimethoxysilane (CAS 18551-20-7)
- 3,4-Difluoro-N-isopropylbenzenesulfonamide (CAS 898074-42-5)
- (S)-2-Amino-1-(4-(benzyl(cyclopropyl)amino)piperidin-1-yl)propan-1-one (CAS 1354015-62-5)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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