Pomalidomide Impurity 1 CAS 1001852-14-7
| CAS No. | 1001852-14-7 |
| Molecular Formula | C13H13N3O5 |
| Molecular Weight | 291.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Pomalidomide Impurity 1 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 291.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Pomalidomide Impurity 1 (CAS 1001852-14-7, C13H13N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Pomalidomide Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13N3O5 |
| Molecular Weight | 291.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 3 |
Related Pomalidomide Standards
- Pomalidomide Impurity 2 (CAS 1001852-15-8)
- Pomalidomide Impurity 3 (CAS 2635-64-5)
- Pomalidomide Impurity 4 (CAS 918314-45-1)
- Pomalidomide Impurity 54 (CAS CATO-C4X-135454)
- Pomalidomide Impurity 58 (CAS 18658-36-1)
- Pomalidomide M17 (CAS 1547162-41-3)
- Pomalidomide M16 (CAS 1547162-46-8)
- Pomalidomide M19 (CAS 460741-57-5)
Recommended Standards
- Vengicide (CAS 606-58-6)
- N-Methyl-2-((1-methyl-6-nitro-2-oxo-1,2-dihydroquinolin-3-yl)oxy)acetamide (CAS 2230408-08-7)
- N6-Ethenoadenosine (CAS 39007-51-7)
- N-((3-(5-Nitrofuran-2-yl)-1H-pyrazol-4-yl)methylene)morpholin-4-amine (CAS 61620-12-0)
- Teprenone Impurity 9 (CAS CATO-C4X-20819)
- Abiraterone Impurity 79 (CAS 2697127-16-3)
- Empagliflozin Impurity 161 (CAS 1620758-25-9/1620758-26-0)
- Ethyl 3-ethyl-5-methyl-1,2-oxazole-4-carboxylate (CAS 53064-41-8)
- 2-(3-Butoxyphenyl)-8-chloroquinoline-4-carbonyl chloride (CAS 1160255-94-6)
- Methyl 4,5,6,7-tetrahydro-1-benzothiophene-7-carboxylate (CAS 110449-91-7)
- 3-(aminomethyl)-1-methylcyclobutan-1-ol hydrochloride (CAS 2173105-60-5)
- 2,2-difluoro-2H-1,3-benzodioxole-5-sulfonamide (CAS 1710471-90-1)
- 3-Methyl-N-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-yl)methyl)butan-1-amine hydrochloride (CAS 1856045-99-2)
- Fibrinogen Related Peptide (CAS 80755-86-8)
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