Diethyl 2-(4-chlorobutyl)malonate CAS 18719-44-3
| CAS No. | 18719-44-3 |
| Molecular Formula | C11H19ClO4 |
| Molecular Weight | 250.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Diethyl 2-(4-chlorobutyl)malonate is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Diethyl 2-(4-chlorobutyl)malonate (CAS 18719-44-3), molecular formula C11H19ClO4 and molecular weight 250.72 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, Diethyl 2-(4-chlorobutyl)malonate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 250.72 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H19ClO4 |
| Molecular Weight | 250.72 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
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Recommended Standards
- 2-Chloro-4-isobutyl-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile (CAS 1779124-89-8)
- (1-(4-Chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)cyclopentyl)methanol (CAS 2173992-18-0)
- 3-(4-(Tert-butyl)phenyl)-5-(chloromethyl)-1,2,4-oxadiazole (CAS 175204-40-7)
- (1-(5-Chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)cyclopentyl)methanol (CAS 2173992-11-3)
- 2-(Pyridin-3-yl)thiazol-5-amine hydrochloride (CAS 1269054-63-8)
- Bis(2-bromo-4-methylphenyl)amine (CAS 27996-13-0)
- {[2-(Benzyloxy)phenyl]methyl}(propyl)amine (CAS 869953-21-9)
- N-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)aniline (CAS 1073353-90-8)
- (S)-5-((4-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxypiperidin-1-yl)methyl)-3-(4-methoxyphenyl)oxazolidin-2-one (CAS 139225-22-2)
- 5-[(4-butylphenyl)amino]-1,3,4-thiadiazole-2-thiol (CAS 750613-93-5)
- (3E)-4-(4-Methoxyphenyl)-3-(methyl carboxy)but-3-enoic acid (CAS 86017-93-8)
- N,n,n,n-tetraallyl1,4-diaminobutane (CAS 54391-08-1)
- 3-Fluoro-4-hydroxy-2-(trifluoromethyl)pyridine (CAS 1227515-79-8)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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