Lornoxicam Impurity 1 CAS 187746-97-0
| CAS No. | 187746-97-0 |
| Molecular Formula | C5H3ClO4S2 |
| Molecular Weight | 226.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lornoxicam Impurity 1.
Lornoxicam Impurity 1 (CAS 187746-97-0) is a certified pharmaceutical impurity reference standard with the molecular formula C5H3ClO4S2 and a molecular weight of 226.66 g/mol.
Owing to a carbohydrate-derived structure, a sulfone group, chlorine substitution, Lornoxicam Impurity 1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 226.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3ClO4S2 |
| Molecular Weight | 226.66 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 2 |
Related Lornoxicam Standards
- Lornoxicam impurity 94 (CAS CATO-C4X-201694)
- Lornoxicam Impurity 42 (CAS CATO-C4X-201642)
- Lornoxicam Impurity 26 (CAS 59804-27-2)
- Lornoxicam Impurity 16 (CAS 72975-44-1)
- Lornoxicam Impurity 41 (CAS CATO-C4X-201641)
- Lornoxicam Impurity 34 (CAS 1333316-61-2)
- Lornoxicam impurity 62 (CAS CATO-C4X-201662)
- Lornoxicam impurity 70 (CAS CATO-C4X-201670)
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