5-(4-Chlorophenyl)nicotinic Acid CAS 187999-33-3
| CAS No. | 187999-33-3 |
| Molecular Formula | C12H8ClNO2 |
| Molecular Weight | 233.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(4-Chlorophenyl)nicotinic Acid.
5-(4-Chlorophenyl)nicotinic Acid (CAS 187999-33-3) is a high-purity analytical reference standard with the molecular formula C12H8ClNO2 and a molecular weight of 233.65 g/mol.
Based on its molecular formula C12H8ClNO2, 5-(4-Chlorophenyl)nicotinic Acid contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 233.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(4-Chlorophenyl)nicotinic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClNO2 |
| Molecular Weight | 233.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorophenyl Standards
- 2-(4-Chlorophenyl)nicotinic acid (CAS 101419-79-8)
- 4-(3-Chlorophenyl)picolinic acid (CAS 1207725-34-5)
- 2-(3-Chlorophenyl)isonicotinic acid (CAS 1207725-71-0)
- 5-(2-Chlorophenyl)picolinic acid (CAS 1221403-88-8)
- 3-(3-Chlorophenyl)picolinic acid (CAS 1225514-91-9)
- 2-(2-Chlorophenyl)isonicotinic acid (CAS 1225547-10-3)
- 5-(3-Chlorophenyl)picolinic acid (CAS 1225547-21-6)
- 2-(2-Chlorophenyl)nicotinic acid (CAS 1226215-53-7)
Recommended Standards
- 4-Cyano-2-fluoro-3-methylbenzene-1-sulfonyl chloride (CAS 1807296-20-3)
- (2e)-3-(7-Chloroquinolin-2-yl)prop-2-enoic acid (CAS 59394-19-3)
- 4-Chloro-6-(4,4-difluoropiperidin-1-yl)pyrimidine (CAS 1590398-25-6)
- (3-Amino-6-chloropyrazin-2-yl)(phenyl)methanone (CAS 56414-04-1)
- 3-Acetylimidazo[1,2-a]pyridin-2(3H)-one (CAS 129820-74-2)
- 2-Isopropyl-4-methylphenol (CAS 4427-56-9)
- ethyl 5-(4-chlorophenyl)-1-methyl-1H-pyrazole-3-carboxylate (CAS 864426-88-0)
- 5-chloro-1-pentyne (CAS 14267-92-6)
- 7-(Bromomethyl)-1-methylnaphthalene (CAS 1261799-27-2)
- Sepiapterin Impurity 26 (CAS 13039-69-5)
- 3-(2-Fluorophenyl)-1-methylpiperazine-2,5-dione (CAS 1214856-65-1)
- 4-Chloro-4'-morpholinomethyl benzophenone (CAS 898770-11-1)
- 4-Methoxy-5-(piperazin-1-yl)pyridin-2-amine (CAS 2311864-26-1)
- endo-Arg30-Semaglutide (CAS CATO-C4X-2226281)
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