1-Chloro-3-propoxy-5-(trifluoromethyl)benzene CAS 1881330-65-9
| CAS No. | 1881330-65-9 |
| Molecular Formula | C10H10ClF3O |
| Molecular Weight | 238.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-Chloro-3-propoxy-5-(trifluoromethyl)benzene (CAS 1881330-65-9), molecular formula C10H10ClF3O and molecular weight 238.63 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-Chloro-3-propoxy-5-(trifluoromethyl)benzene (C10H10ClF3O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10ClF3O |
| Molecular Weight | 238.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 4-Chloro-7-methoxy-3-nitroquinoline (CAS 1026963-05-2)
- 4-chloro-3-(5-methyl-1h-1,2,3,4-tetraZol-1-yl)benzoic acid (CAS 1156373-88-4)
- 5-(3-Chloro-4-methylphenyl)-1,2,4-oxadiazole-3-carboxylic acid (CAS 1342109-95-8)
- 2-CHloro-1-(propan-2-yloxy)-4-(trifluoromethyl)benzene (CAS 1369830-55-6)
- 1-CHloro-3-(propan-2-yloxy)-5-(trifluoromethyl)benzene (CAS 1369839-32-6)
- 1-CHloro-4-(propan-2-yloxy)-2-(trifluoromethyl)benzene (CAS 1369877-52-0)
- 1-CHloro-2-(propan-2-yloxy)-4-(trifluoromethyl)benzene (CAS 1369940-70-4)
- Methyl 7-chloro-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (CAS 1386448-06-1)
Recommended Standards
- 4-Chloro-1-propoxy-2-(trifluoromethyl)benzene (CAS 1881330-61-5)
- Methyl 2-chloro-5-(1H-tetrazol-1-yl)benzoate (CAS 190270-11-2)
- 1-Chloro-4-propoxy-2-(trifluoromethyl)benzene (CAS 1881321-74-9)
- (3,5-Diamino-6-chloropyrazin-2-yl)(1H-imidazol-1-yl)methanone (CAS 76962-94-2)
- 4-Cyclopropoxy-2-methoxynicotinaldehyde (CAS 1243349-65-6)
- alpha-(Trifluoromethyl)-2,3-dihydrobenzofuran-5-methanol (CAS 342891-38-7)
- 2-(1-(Thiophen-2-ylmethyl)cyclohexyl)acetic acid (CAS 78645-45-1)
- 1-(4-Iodophenyl)hexan-1-one (CAS 160565-78-6)
- 2-Ethoxy-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (CAS 1355614-13-9)
- (2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methanol (CAS 317319-27-0)
- 2-(2-Bromo-5-(difluoromethyl)-3-nitropyridin-4-yl)acetic acid (CAS 1806916-66-4)
- 1,5-bis(3,4-dichlorophenyl)penta-1,4-dien-3-one (CAS 42160-05-4)
- 7-Bromo-1H-indol-6-amine (CAS 214279-28-4)
- Semaglutide impurity 87 (CAS CATO-C4X-222687)
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