N-(5-Bromo-2-fluoro-3-nitrophenyl)-2,2,2-trifluoroacetamide CAS 1881331-03-8
| CAS No. | 1881331-03-8 |
| Molecular Formula | C8H3BrF4N2O3 |
| Molecular Weight | 331.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(5-Bromo-2-fluoro-3-nitrophenyl)-2,2,2-trifluoroacetamide.
N-(5-Bromo-2-fluoro-3-nitrophenyl)-2,2,2-trifluoroacetamide (CAS 1881331-03-8), molecular formula C8H3BrF4N2O3 and molecular weight 331.02 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, N-(5-Bromo-2-fluoro-3-nitrophenyl)-2,2,2-trifluoroacetamide (C8H3BrF4N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 331.02 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(5-Bromo-2-fluoro-3-nitrophenyl)-2,2,2-trifluoroacetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H3BrF4N2O3 |
| Molecular Weight | 331.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-(2-BRomo-5-fluoro-4-nitro-phenyl)-2,2,2-trifluoro-acetamide (CAS 2092929-90-1)
- 4-Bromo-1-(4-bromobenzyl)-1,2-dihydro-3h-pyrazol-3-imine (CAS 956440-81-6)
- 5-Bromo-8-(bromomethyl)-2-methoxyquinoline (CAS 885687-81-0)
- 7-Bromo-8-(bromomethyl)-2-methoxyquinoline (CAS 944407-50-5)
- 2-(6-Bromo-2-fluoro-3-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1070871-08-7)
- 5-bromo-4-iodo-1H-pyrrolo[2,3-b]pyridine (CAS 1092580-04-5)
- 3-bromo-6-iodo-imidazo[1,2-a]pyridine (CAS 1146615-52-2)
- 2-(4-Bromo-2-fluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1150271-71-8)
Recommended Standards
- 3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1012085-50-5)
- 4-Chloro-5-methyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine 6104AC 942920-17-4 C17H27ClN2Si (CAS 942920-17-4)
- Methyl 3-iodo-6-(trifluoromethyl)picolinate (CAS 1256785-78-0)
- Methyl 3-iodo-5-(trifluoromethyl)picolinate (CAS 1360900-67-9)
- Methyl 4-Bromoindole-3-acetate (CAS 89245-37-4)
- 2,6-Diethylbenzoyl chloride (CAS 64359-02-0)
- Ethyl 7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 71083-05-1)
- (2S,3R,4S,5S,6S)-6-(Bromomethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol (CAS 28528-87-2)
- Glufosinate-D3 (CAS 1323486-77-6)
- 3-((1,1-Dioxidothiomorpholino)methyl)benzonitrile (CAS 1154976-28-9)
- (4-Methoxybenzyl)triphenylphosphonium chloride (CAS 3462-97-3)
- (S)-Naringenin (CAS 480-41-1)
- 3-(4-Methoxyphenyl)-2-(((tetrahydro-2H-pyran-2-yl)methyl)thio)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (CAS 618431-95-1)
- Des-Pro31-Tirzepatide (CAS CATO-CPTD788943)
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