3-Bromo-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one CAS 188533-07-5
| CAS No. | 188533-07-5 |
| Molecular Formula | C11H11BrFNO |
| Molecular Weight | 272.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Bromo-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one (CAS 188533-07-5) is a high-purity analytical reference standard with the molecular formula C11H11BrFNO and a molecular weight of 272.11 g/mol.
The molecular framework of 3-Bromo-1-[(4-fluorophenyl)methyl]pyrrolidin-2-one (C11H11BrFNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H11BrFNO |
| Molecular Weight | 272.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 1-(4-bromo-2-fluorophenyl)piperidin-2-one (CAS 1016773-90-2)
- 1-(4-Bromo-2-fluorobenzyl)pyrrolidin-2-one (CAS 1022931-60-7)
- 1-[(4-Bromo-3-fluorophenyl)carbonyl]pyrrolidine (CAS 1022931-81-2)
- 1-(2-Bromo-4-fluorophenyl)piperidin-2-one (CAS 1038980-58-3)
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Recommended Standards
- 4-Bromo-3-fluoro-N-(1-methylcyclopropyl)benzamide (CAS 1779290-79-7)
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- 6-Bromo-5-fluoro-1,3,3-trimethylindolin-2-one (CAS 1581753-73-2)
- (4-Bromo-2-fluorophenyl)(pyrrolidin-1-yl)methanone (CAS 882689-88-5)
- 7-hydroxy-1-methyl-2,3-dihydro-1H-indol-2-one (CAS 20870-84-2)
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- (1S,3S)-1-Amino-3-methylcyclopentanecarboxylic acid (CAS 52521-23-0)
- 3-amino-5-chloro-pyrazine-2-carboxylic acid (CAS 1260663-68-0)
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