Argatroban Impurity 7 CAS 188659-43-0
| CAS No. | 188659-43-0 |
| Molecular Formula | C22H34N4O5S |
| Molecular Weight | 466.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Argatroban Impurity 7 (CAS 188659-43-0) is a certified pharmaceutical impurity reference standard with the molecular formula C22H34N4O5S and a molecular weight of 466.59 g/mol.
The molecular framework of Argatroban Impurity 7 (C22H34N4O5S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H34N4O5S |
| Molecular Weight | 466.59 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Argatroban Standards
- Argatroban Impurity 45 (CAS CATO-C4X-100745)
- Argatroban Impurity 129 (CAS CATO-C4X-1007129)
- Argatroban Impurity 130 (CAS CATO-C4X-1007130)
- Argatroban Impurity 131 (CAS CATO-C4X-1007131)
- Argatroban Impurity 34 (CAS 74874-07-0)
- Argatroban Impurity 91 (CAS CATO-C4X-100791)
- Argatroban Impurity 118 (CAS CATO-C4X-1007118)
- Argatroban Impurity 119 (CAS CATO-C4X-1007119)
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