Afoxolaner Impurity 14 CAS 1125726-30-8
| CAS No. | 1125726-30-8 |
| Molecular Formula | C22H13BrF6O4 |
| Molecular Weight | 535.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Afoxolaner Impurity 14 (CAS 1125726-30-8), a pharmacopoeial impurity reference standard (molecular formula C22H13BrF6O4, MW 535.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Afoxolaner Impurity 14 (C22H13BrF6O4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Afoxolaner Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H13BrF6O4 |
| Molecular Weight | 535.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Br-containing |
Related Afoxolaner Standards
- Afoxolaner Impurity 19 (CAS CATO-C4X-313719)
- Afoxolaner impurity 8 (CAS CATO-C4X-31378)
- Afoxolaner Impurity 17 (CAS CATO-C4X-313717)
- Afoxolaner impurity 4 (CAS CATO-C4X-31374)
- Afoxolaner Impurity 24 (CAS 1352722-19-0)
- Afoxolaner Impurity 15 (CAS CATO-C4X-313715)
- Afoxolaner Impurity 20 (CAS 1125812-60-3)
- Afoxolaner impurity 5 (CAS CATO-C4X-31375)
Recommended Standards
- N-[1-[3,5-bis(trifluoromethyl)phenyl]-3-(2-furyl)-1H-pyrazol-5-yl]-2,6-dichloroisonicotinamide (CAS 849066-61-1)
- 2-((4-(4-Bromophenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3,5-dichlorophenyl)acetamide (CAS 477330-01-1)
- Chlorodihydrido[bis(2-di-i-propylphosphinoethyl)amine]iridium(III) (CAS 791629-96-4)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3,5-dichlorophenyl)acetamide (CAS 477331-02-5)
- Pimecrolimus Impurity 11 (CAS CATO-C4X-173111)
- Trenbolone Impurity 4 (CAS CATO-C4X-24744)
- Cariprazine Impurity 17 (CAS 1698050-40-6)
- (3S,5S)-5-methylpyrrolidin-3-ol hydrochloride (CAS 1107658-77-4)
- N,3-dimethylthiophene-2-carboxamide (CAS 56776-68-2)
- Potassium 2-(2,4,5-trichlorophenoxy)acetate (CAS 37785-57-2)
- N-Methyl-N-(piperidin-4-yl)acetamide (CAS 83180-55-6)
- 4-((3-Amino-2H-indazol-2-yl)methyl)-N-(2-aminophenyl)benzamide (CAS 920315-49-7)
- 2-Acetyl-6-iodoisonicotinonitrile (CAS 1393544-62-1)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com