Docetaxel EP Impurity A CAS 1887057-05-7
| CAS No. | 1887057-05-7 |
| Molecular Formula | C41H55NO14 |
| Molecular Weight | 785.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Docetaxel EP Impurity A (CAS 1887057-05-7, C41H55NO14) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Docetaxel EP Impurity A (C41H55NO14) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 785.87 g/mol, it falls into the high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Docetaxel EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C41H55NO14 |
| Molecular Weight | 785.87 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Nitrogen Atoms | 1 |
Related Docetaxel Standards
- Docetaxel Impurity 54 (CAS 173101-47-8)
- Docetaxel EP Impurity B (CAS 167074-97-7)
- Docetaxel EP Impurity D (CAS 162784-72-7)
- Docetaxel Impurity 8 (CAS CATO-C4X-16198)
- Docetaxel EP Impurity B (CAS CATO-C4X-161980)
- Docetaxel (Anhydrous) (CAS 114977-28-5)
- Docetaxel EP Impurity C (CAS 153381-68-1)
- Docetaxel Impurity 49 (CAS 1095547-86-6)
Recommended Standards
- 66687-07-8 4-[4-[[4-(4-aminooxysulfonylanilino)phenyl]-[4-(4-aminooxysulfonylphenyl)iminocyclohexa-2,5-dien-1-ylidene]methyl]anilino]benzenesulfonic acid DTXSID50422995 (CAS 66687-07-8)
- 2-Debenzoxyl 2-pentenoyl docetaxel (CAS 1412898-66-8)
- 5-Me-dC(Ac) amidite (CAS 1873306-74-1)
- Rifaximin (CAS 80621-81-4)
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- 1-(1,3-Dioxan-5-yl)-N,N-dimethyl-1-(pyridin-3-yl)methanamine (CAS 62938-80-1)
- 4-Methoxy(toluene-d7) (CAS 1036431-36-3)
- 2,3-Dicyano-5-hydroxypyrazine (CAS 57005-60-4)
- (1S)-3,3'-Diphenyl[1,1'-binaphthalene]-2,2'-dicarboxylic acid (CAS 1791455-27-0)
- (3,5-Dichloropyridin-4-yl)(phenyl)methanol (CAS 402561-69-7)
- Palmitoyl Tetrapeptide-7 (CAS 221227-05-0)
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