Ziprasidone Impurity 3 CAS 188797-77-5
| CAS No. | 188797-77-5 |
| Molecular Formula | C21H21ClN4O3S |
| Molecular Weight | 444.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ziprasidone Impurity 3 (CAS 188797-77-5, C21H21ClN4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C21H21ClN4O3S, Ziprasidone Impurity 3 contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 444.93 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ziprasidone Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C21H21ClN4O3S |
| Molecular Weight | 444.93 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Ziprasidone Standards
- Ziprasidone Impurity 63 (CAS CATO-C4X-124063)
- Ziprasidone Impurity 64 (CAS CATO-C4X-124064)
- Ziprasidone Impurity 46 (CAS 2369664-19-5)
- Ziprasidone Impurity 2 (CAS 684269-12-3)
- Ziprasidone Impurity 70 (CAS CATO-C4X-124070)
- Ziprasidone EP Impurity C (CAS 1159977-64-6)
- Ziprasidone Impurity 11 (CAS 188797-76-4)
- Ziprasidone Impurity 12 (CAS 884305-08-2)
Recommended Standards
- Vercirnon (CAS 698394-73-9)
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- Dodecamethylpentasiloxane (CAS 540-97-6)
- Methyl 2,4,5-tris(bromomethyl)-3-methoxybenzoate (CAS 2830607-01-5)
- Apalutamide Impurity 76 (CAS CATO-C4X-274976)
- Ceftazidime Impurity 23 (CAS 158183-05-2)
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- 4-Methyl-1-(propan-2-yl)-1H,6H,7H-pyrazolo[3,4-b]pyridin-6-one (CAS 929975-11-1)
- 4,4,5,5-Tetramethyl-2-(2-propylphenyl)-1,3,2-dioxaborolane (CAS 2098356-55-7)
- Butyraldehyde 2,4-Dinitrophenylhydrazone-3,5,6-d3 (CAS 259824-54-9)
- 3-Chloro-N-[2-(dimethylamino)ethyl]-N-methyl-5-(trifluoromethyl)pyridin-2-amine (CAS 338406-19-2)
- 4-{[(2-methoxyethyl)amino]methyl}benzonitrile hydrochloride (CAS 1251923-40-6)
- Tetrabenazine Impurity 48 (CAS 1214267-46-5)
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