Imatinib Impurity 99 CAS 189037-78-3
| CAS No. | 189037-78-3 |
| Molecular Formula | C16H12Cl2O3 |
| Molecular Weight | 323.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Imatinib Impurity 99.
CATO supplies Imatinib Impurity 99 (CAS 189037-78-3), a pharmacopoeial impurity reference standard (molecular formula C16H12Cl2O3, MW 323.17 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Imatinib Impurity 99 (C16H12Cl2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl2O3 |
| Molecular Weight | 323.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2011 |
| Halogen Content | Cl-containing |
Related Imatinib Standards
- Imatinib Impurity 74 (CAS CATO-C4X-106874)
- Imatinib Impurity 64 (CAS 1356565-47-3)
- Imatinib Impurity 94 (CAS CATO-C4X-106894)
- Imatinib Impurity 34 (CAS 765269-29-2)
- Imatinib Impurity 76 (CAS CATO-C4X-106876)
- Imatinib Impurity 36 (CAS 475587-23-6)
- Imatinib Impurity 38 (CAS CATO-C4X-106838)
- Imatinib Impurity 39 (CAS 796738-71-1)
Recommended Standards
- Lorazepam Impurity 17 (CAS CATO-C4X-104117)
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- 2-(2-(4-Bromophenyl)-2-oxoethyl)-5-methylcyclohexane-1,3-dione (CAS 112404-26-9)
- Docetaxel EP Impurity B (CAS CATO-C4X-161980)
- Fluconazole Impurity 55 (CAS CATO-C4X-101955)
- Isavuconazole Impurity 13 (CAS CATO-C4X-123613)
- 2-Bromo-1-(5-methylthiophen-2-yl)ethanone (CAS 10531-42-7)
- 2-Ethoxy-5-fluoroaniline (CAS 946774-81-8)
- (3-((4-(Tert-butoxycarbonyl)piperazin-1-yl)sulfonyl)-4-methylphenyl)boronic acid (CAS 1704066-78-3)
- p-Tolyl(5-(p-tolyl)-1H-1,2,4-triazol-3-yl)methanamine (CAS 1707735-85-0)
- Kaempferol 5,7,4'-trimethyl ether (CAS 1098-92-6)
- 2-Methyl-5-(pentan-2-yl)furan (CAS 94922-72-2)
- D-Ser12-Semaglutide (CAS CATO-C4X-2226240)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com